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The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock
https://oist.repo.nii.ac.jp/records/1028
https://oist.repo.nii.ac.jp/records/1028269f3a04-1c74-4427-b322-4c3bab7deca0
名前 / ファイル | ライセンス | アクション |
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Myung-2019-The Kidney Clock Contributes to Tim (2.6 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Myung, Jihwan
× Myung, Jihwan× Wu, Mei-Yi× Lee, Chun-Ya× Rahim, Amalia Ridla× Truong, Vuong Hung× Wu, Dean× Piggins, Hugh David× Wu, Mai-Szu |
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書誌情報 |
en : International Journal of Molecular Sciences 巻 20, 号 11, p. 2765, 発行日 2019-06-05 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with a longer period. We find this analogous to the silencing of a strong slave clock in the brain, the choroid plexus, which alters the pacing of the SCN. We propose that the kidney also contributes to overall circadian timekeeping at the whole-body level, through bottom-up feedback in the hierarchical structure of the mammalian circadian clocks. | |||||
出版者 | ||||||
出版者 | MDPI AG, Basel, Switzerland | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1422-0067 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1661-6596 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31195684 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3390/ijms20112765 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.mdpi.com/1422-0067/20/11/2765 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |