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Ca2+ Requirements for Long-Term Depression Are Frequency Sensitive in Purkinje Cells
https://oist.repo.nii.ac.jp/records/1043
https://oist.repo.nii.ac.jp/records/1043a3154dec-527c-4e51-b9e6-343e30805b4b
名前 / ファイル | ライセンス | アクション |
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Zamora Chimal-2018-Ca(2+) Requirements for Lon (3.3 MB)
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Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-30 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Ca2+ Requirements for Long-Term Depression Are Frequency Sensitive in Purkinje Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zamora Chimal, C. G.
× Zamora Chimal, C. G.× De Schutter, Erik |
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書誌情報 |
en : Frontiers in Molecular Neuroscience 巻 11, p. 438, 発行日 2018-12-04 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cerebellar long-term depression (LTD) is a form of synaptic plasticity dependent on postsynaptic Ca(2+) changes. One fundamental question is how LTD is selectively induced by specific numbers of Ca(2+) pulses and which are the frequency and duration of this train of pulses required for LTD induction. The molecular mechanism which leads the integration of postsynaptic Ca(2+) pulses in the LTD signaling network has not been elucidated either. Recent publications have shown that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is required for LTD induction. Additionally, protein kinase C (PKC), CaMKII, and MAPK play an important role to transduce the frequency of Ca(2+) pulses into their enzymatic activity levels; however, it is still unknown which enzymes are involved in decoding Ca(2+) pulses in LTD. We have extended a stochastic model of LTD by adding the molecular network regulating CaMKII activity and its activation. We solved this model with stochastic engine for pathway simulation to include the effect of biochemical noise in LTD. We systematically investigated the dependence of LTD induction on stimulus frequencies, and we found that LTD is selectively induced by a specific number of Ca(2+) spikes at different frequencies. We observed that CaMKII is essential to induce LTD, and LTD is only weakly induced when its Thr286 phosphorylation site has been deleted. We found that CaMKII decodes the frequency of Ca(2+) spikes into different amounts of kinase activity during LTD induction. In addition, PKC and ERK enzyme activity is highly sensitive to the frequency and the number of Ca(2+) pulses and this sensitivity has an important effect on LTD activation. This research predicts the postsynaptic Ca(2+) requirements to induce LTD using a typical synaptic activation sequence and explains how LTD is selectively induced by specific number of Ca(2+) pulses at different frequencies. | |||||
出版者 | ||||||
出版者 | Frontiers Media | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1662-5099 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30564097 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fnmol.2018.00438 | |||||
権利 | ||||||
権利情報 | © 2018 Zamora Chimal and De Schutter. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fnmol.2018.00438/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |