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A genome-wide assessment of the ancestral neural crest gene regulatory network
https://oist.repo.nii.ac.jp/records/1296
https://oist.repo.nii.ac.jp/records/129646155805-0115-446e-b4d4-29f00a3199d6
名前 / ファイル | ライセンス | アクション |
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Hockman-2019-A genome-wide assessment of the a (5.0 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A genome-wide assessment of the ancestral neural crest gene regulatory network | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Hockman, Dorit
× Hockman, Dorit× Chong-Morrison, Vanessa× Green, Stephen A.× Gavriouchkina, Daria× Candido-Ferreira, Ivan× Ling, Irving T. C.× Williams, Ruth M.× Amemiya, Chris T.× Smith, Jeramiah J.× Bronner, Marianne E.× Sauka-Spengler, Tatjana |
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書誌情報 |
en : Nature Communications 巻 10, 号 1, p. 4689, 発行日 2019-10-16 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The neural crest (NC) is an embryonic cell population that contributes to key vertebrate-specific features including the craniofacial skeleton and peripheral nervous system. Here we examine the transcriptional and epigenomic profiles of NC cells in the sea lamprey, in order to gain insight into the ancestral state of the NC gene regulatory network (GRN). Transcriptome analyses identify clusters of co-regulated genes during NC specification and migration that show high conservation across vertebrates but also identify transcription factors (TFs) and cell-adhesion molecules not previously implicated in NC migration. ATAC-seq analysis uncovers an ensemble of cis-regulatory elements, including enhancers of Tfap2B, SoxE1 and Hox-alpha2 validated in the embryo. Cross-species deployment of lamprey elements identifies the deep conservation of lamprey SoxE1 enhancer activity, mediating homologous expression in jawed vertebrates. Our data provide insight into the core GRN elements conserved to the base of the vertebrates and expose others that are unique to lampreys. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31619682 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-019-12687-4 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s) | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-019-12687-4#Abs1 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |