WEKO3
アイテム
{"_buckets": {"deposit": "6ac84690-df4d-49a0-aef2-dc8a70ff5894"}, "_deposit": {"created_by": 30, "id": "1394", "owners": [30], "pid": {"revision_id": 0, "type": "depid", "value": "1394"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00001394", "sets": ["67"]}, "author_link": ["8440", "8441", "8439", "8442"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-10-18", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "177", "bibliographicPageStart": "172", "bibliographicVolumeNumber": "521", "bibliographic_titles": [{}, {"bibliographic_title": "Biochemical and Biophysical Research Communications", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, Toru"}], "nameIdentifiers": [{"nameIdentifier": "8439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuguchi, Chisato"}], "nameIdentifiers": [{"nameIdentifier": "8440", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishijima, Saori"}], "nameIdentifiers": [{"nameIdentifier": "8441", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "8442", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "Abnormal hair loss results from a variety of factors, such as metabolic dysfunctions, immunodeficiency, and environmental stressors. Here, we report that mutant mice having defects in liver function, develop alopecia. We have shown previously that in mice lacking a Cnot3 gene, which encodes an essential component of the CCR4-NOT deadenylase complex in liver (Cnot3-LKO mice), the liver does not mature properly, resulting in various pathologies such as hepatitis, hepatic necrosis, and anemia. Unexpectedly, Cnot3-LKO mice start to lose hair around postnatal day 17 (P17). The region of hair loss expands all across their backs and symptoms persist until around P28-30. Afterward, hair re-grows, and Cnot3-LKO mice show complete hair recovery by P40. The phenotype is dependent on mouse genotype, indicating that hair follicle morphogenesis and cycling are influenced by abnormal liver development. By performing histological, quantitative PCR, and immunoblot analyses, we detected sebaceous gland (SG) hypertrophy accompanied by an increase of peroxisome proliferator-activated receptor gamma (PPARgamma). Collectively, these findings suggest that paracrine signaling related to liver function influences hair growth, at least in part, by altering lipid metabolism.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/31630801 ", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.bbrc.2019.10.099", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://creativecommons.org/licenses/by-nc-nd/4.0/"}]}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.sciencedirect.com/science/article/pii/S0006291X19320017", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2019 The Author(s)"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-04-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Suzuki-2020-Insufficient liver maturation affe.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "Suzuki-2020-Insufficient liver maturation affe", "url": "https://oist.repo.nii.ac.jp/record/1394/files/Suzuki-2020-Insufficient liver maturation affe.pdf"}, "version_id": "6a3683b7-c0f9-47aa-87c8-1907ff3ee970"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Insufficient liver maturation affects murine early postnatal hair cycle", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Insufficient liver maturation affects murine early postnatal hair cycle", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "30", "path": ["67"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/1394", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-04-23"}, "publish_date": "2020-04-23", "publish_status": "0", "recid": "1394", "relation": {}, "relation_version_is_last": true, "title": ["Insufficient liver maturation affects murine early postnatal hair cycle"], "weko_shared_id": 30}
Insufficient liver maturation affects murine early postnatal hair cycle
https://oist.repo.nii.ac.jp/records/1394
https://oist.repo.nii.ac.jp/records/13944c8fd485-b8b3-4c77-98c9-807099bf3794
名前 / ファイル | ライセンス | アクション |
---|---|---|
Suzuki-2020-Insufficient liver maturation affe (1.9 MB)
|
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-04-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Insufficient liver maturation affects murine early postnatal hair cycle | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Suzuki, Toru
× Suzuki, Toru× Kikuguchi, Chisato× Nishijima, Saori× Yamamoto, Tadashi |
|||||
書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 521, 号 1, p. 172-177, 発行日 2019-10-18 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Abnormal hair loss results from a variety of factors, such as metabolic dysfunctions, immunodeficiency, and environmental stressors. Here, we report that mutant mice having defects in liver function, develop alopecia. We have shown previously that in mice lacking a Cnot3 gene, which encodes an essential component of the CCR4-NOT deadenylase complex in liver (Cnot3-LKO mice), the liver does not mature properly, resulting in various pathologies such as hepatitis, hepatic necrosis, and anemia. Unexpectedly, Cnot3-LKO mice start to lose hair around postnatal day 17 (P17). The region of hair loss expands all across their backs and symptoms persist until around P28-30. Afterward, hair re-grows, and Cnot3-LKO mice show complete hair recovery by P40. The phenotype is dependent on mouse genotype, indicating that hair follicle morphogenesis and cycling are influenced by abnormal liver development. By performing histological, quantitative PCR, and immunoblot analyses, we detected sebaceous gland (SG) hypertrophy accompanied by an increase of peroxisome proliferator-activated receptor gamma (PPARgamma). Collectively, these findings suggest that paracrine signaling related to liver function influences hair growth, at least in part, by altering lipid metabolism. | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31630801 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.bbrc.2019.10.099 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s) | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0006291X19320017 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |