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Bifractal nature of chromosome contact maps
https://oist.repo.nii.ac.jp/records/1816
https://oist.repo.nii.ac.jp/records/181660fd3eb6-e5d2-490c-b6f2-af576e476d75
名前 / ファイル | ライセンス | アクション |
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Pigolotti-2020-Bifractal nature of chromosome (1.4 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Bifractal nature of chromosome contact maps | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Pigolotti, Simone
× Pigolotti, Simone× Jensen, Mogens H.× Zhan, Yinxiu× Tiana, Guido |
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書誌情報 |
en : Physical Review Research 巻 2, 号 4, p. 043078, 発行日 2020-10-15 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Modern biological techniques such as Hi-C permit one to measure probabilities that different chromosomal regions are close in space. These probabilities can be visualized as matrices called contact maps. In this paper, we introduce a multifractal analysis of chromosomal contact maps. Our analysis reveals that Hi-C maps are bifractal, i.e., complex geometrical objects characterized by two distinct fractal dimensions. To rationalize this observation, we introduce a model that describes chromosomes as a hierarchical set of nested domains and we solve it exactly. The predicted multifractal spectrum is in excellent quantitative agreement with experimental data. Moreover, we show that our theory yields a more robust estimation of the scaling exponent of the contact probability than existing methods. By applying this method to experimental data, we detect subtle conformational changes among chromosomes during differentiation of human stem cells. | |||||
出版者 | ||||||
出版者 | American Physical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2643-1564 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1103/PhysRevResearch.2.043078 | |||||
権利 | ||||||
権利情報 | © 2020 American Physical Society | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.aps.org/prresearch/abstract/10.1103/PhysRevResearch.2.043078 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |