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Transcription levels of a noncoding RNA orchestrate opposing regulatory and cell fate outcomes in yeast
https://oist.repo.nii.ac.jp/records/2066
https://oist.repo.nii.ac.jp/records/2066bfee4084-4a1c-42d2-a2fd-62158d9601ca
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S2211124720316326-main (4.7 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-05-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Transcription levels of a noncoding RNA orchestrate opposing regulatory and cell fate outcomes in yeast | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IME1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lncRNA | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | meiosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rtt109 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | yeast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | transcription | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chromatin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cell fate | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | H3K56ac | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rme1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Moretto, Fabien
× Moretto, Fabien× Wood, N. Ezgi× Chia, Minghao× Li, Cai× Luscombe, Nicholas M.× van Werven, Folkert J. |
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書誌情報 |
en : Cell Reports 巻 34, 号 3, p. 108643, 発行日 2021-01-19 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Transcription through noncoding regions of the genome is pervasive. How these transcription events regulate gene expression remains poorly understood. Here, we report that, in S. cerevisiae, the levels of transcription through a noncoding region, IRT2, located upstream in the promoter of the inducer of meiosis, IME1, regulate opposing chromatin and transcription states. At low levels, the act of IRT2 transcription promotes histone exchange, delivering acetylated histone H3 lysine 56 to chromatin locally. The subsequent open chromatin state directs transcription factor recruitment and induces downstream transcription to repress the IME1 promoter and meiotic entry. Conversely, increasing transcription turns IRT2 into a repressor by promoting transcription-coupled chromatin assembly. The two opposing functions of IRT2 transcription shape a regulatory circuit, which ensures a robust cell-type-specific control of IME1 expression and yeast meiosis. Our data illustrate how intergenic transcription levels are key to controlling local chromatin state, gene expression, and cell fate outcomes. | |||||
出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33472063 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.celrep.2020.108643 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2211124720316326?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |