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Computational model of recurrent subthalamo-pallidal circuit for generation of parkinsonian oscillations
https://oist.repo.nii.ac.jp/records/208
https://oist.repo.nii.ac.jp/records/208513f010f-c7c0-4978-ae3b-001c87fbe60a
名前 / ファイル | ライセンス | アクション |
---|---|---|
fnana-11-00021 (4.5 MB)
|
Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-12-28 | |||||
タイトル | ||||||
タイトル | Computational model of recurrent subthalamo-pallidal circuit for generation of parkinsonian oscillations | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Computational model of recurrent subthalamo-pallidal circuit for generation of parkinsonian oscillations | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Shouno, Osamu
× Shouno, Osamu× Tachibana, Yoshihisa× Nambu, Atsushi× Doya, Kenji |
|||||
書誌情報 |
en : Frontiers in Neuroanatomy 巻 11, p. 1-15, 発行日 2017-03-21 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Parkinson’s disease is a movement disorder caused by dopamine depletion in the basal ganglia. Abnormally synchronized neuronal oscillations between 8 Hz and 15 Hz in the basal ganglia are implicated in motor symptoms of Parkinson’s disease. However, how these abnormal oscillations are generated and maintained in the dopamine-depleted state is unknown. Based on neural recordings in a primate model of Parkinson’s disease and other experimental and computational evidence, we hypothesized that the recurrent circuit between the subthalamic nucleus (STN) and the external segment of the globus pallidus (GPe) generates and maintains parkinsonian oscillations, and that the cortical excitatory input to the STN amplifies them. To investigate this hypothesis through computer simulations, we developed a spiking neuron model of the STN-GPe circuit by incorporating electrophysiological properties of neurons and synapses. A systematic parameter search by computer simulation identified regions in the space of the intrinsic excitability of GPe neurons and synaptic strength from the GPe to the STN that reproduce normal and parkinsonian states. In the parkinsonian state, reduced firing of GPe neurons and increased GPe-STN inhibition trigger burst activities of STN neurons with strong post-inhibitory rebound excitation, which is usually subject to short-term depression. STN neuronal bursts are shaped into the 8-15-Hz, synchronous oscillations via recurrent interactions of STN and GPe neurons. Furthermore, we show that cortical excitatory input to the STN can amplify or suppress pathological STN oscillations depending on their phase and strength, predicting conditions of cortical inputs to the STN for suppressing oscillations. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1662-5129 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28377699 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fnana.2017.00021 | |||||
権利 | ||||||
権利情報 | © 2017 Shouno, Tachibana, Nambu and Doya. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://journal.frontiersin.org/article/10.3389/fnana.2017.00021/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |