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The Cellular Electrophysiological Properties Underlying Multiplexed Coding in Purkinje Cells
https://oist.repo.nii.ac.jp/records/2098
https://oist.repo.nii.ac.jp/records/2098e61f3402-294a-4237-8afc-cb74d42178da
名前 / ファイル | ライセンス | アクション |
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1850.full (4.1 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-05-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Cellular Electrophysiological Properties Underlying Multiplexed Coding in Purkinje Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | burst-pause computation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cerebellum | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | dendritic spikes | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | linear computation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | multiplexed coding | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Purkinje cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zang, Yunliang
× Zang, Yunliang× De Schutter, Erik |
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書誌情報 |
en : The Journal of Neuroscience 巻 41, 号 9, p. 1850-1863, 発行日 2021-03-03 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neuronal firing patterns are crucial to underpin circuit level behaviors. In cerebellar Purkinje cells (PCs), both spike rates and pauses are used for behavioral coding, but the cellular mechanisms causing code transitions remain unknown. We use a well-validated PC model to explore the coding strategy that individual PCs use to process parallel fiber (PF) inputs. We find increasing input intensity shifts PCs from linear rate-coders to burst-pause timing-coders by triggering localized dendritic spikes. We validate dendritic spike properties with experimental data, elucidate spiking mechanisms, and predict spiking thresholds with and without inhibition. Both linear and burst-pause computations use individual branches as computational units, which challenges the traditional view of PCs as linear point neurons. Dendritic spike thresholds can be regulated by voltage state, compartmentalized channel modulation, between-branch interaction and synaptic inhibition to expand the dynamic range of linear computation or burst-pause computation. In addition, co-activated PF inputs between branches can modify somatic maximum spike rates and pause durations to make them carry analog signals. Our results provide new insights into the strategies used by individual neurons to expand their capacity of information processing. | |||||
出版者 | ||||||
出版者 | Society for Neuroscience | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0270-6474 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1529-2401 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33452223 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1523/JNEUROSCI.1719-20.2020 | |||||
権利 | ||||||
権利情報 | © 2021 Zang and De Schutter. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jneurosci.org/content/41/9/1850 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |