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Reduced purine biosynthesis in humans after their divergence from Neandertals
https://oist.repo.nii.ac.jp/records/2168
https://oist.repo.nii.ac.jp/records/2168bb81f7df-dc75-438a-a283-0f9d0b6ceb1e
名前 / ファイル | ライセンス | アクション |
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Stepanova-2021-Reduced purine biosynthesis in (2.8 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-07-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Reduced purine biosynthesis in humans after their divergence from Neandertals | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Stepanova, Vita
× Stepanova, Vita× Moczulska, Kaja Ewa× Vacano, Guido N× Kurochkin, Ilia× Ju, Xiangchun× Riesenberg, Stephan× Macak, Dominik× Maricic, Tomislav× Dombrowski, Linda× Schörnig, Maria× Anastassiadis, Konstantinos× Baker, Oliver× Naumann, Ronald× Khrameeva, Ekaterina× Vanushkina, Anna× Stekolshchikova, Elena× Egorova, Alina× Tkachev, Anna× Mazzarino, Randall× Duval, Nathan× Zubkov, Dmitri× Giavalisco, Patrick× Wilkinson, Terry G× Patterson, David× Khaitovich, Philipp× Pääbo, Svante |
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書誌情報 |
en : eLife 巻 10, p. e58741, 発行日 2021-05-19 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccinate lyase, which catalyzes two reactions in purine synthesis, occur at lower concentrations in humans. This enzyme carries an amino acid substitution that is present in all humans today but absent in Neandertals. By introducing the modern human substitution into the genomes of mice, as well as the ancestral, Neandertal-like substitution into the genomes of human cells, we show that this amino acid substitution contributes to much or all of the reduction of de novo synthesis of purines in humans. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications, Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33942714 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.58741 | |||||
権利 | ||||||
権利情報 | © 2021 Stepanova et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/58741 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |