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Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
https://oist.repo.nii.ac.jp/records/2389
https://oist.repo.nii.ac.jp/records/2389f36dff71-4363-4ce4-ba89-5c5ef05e12e5
名前 / ファイル | ライセンス | アクション |
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elife-70818-v2 (4.9 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-29 | |||||
タイトル | ||||||
タイトル | Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Chipman, Peter H
× Chipman, Peter H× Fung, Chi Chung Alan× Pazo Fernandez, Alejandra× Sawant, Abhilash× Tedoldi, Angelo× Kawai, Atsushi× Ghimire Gautam, Sunita× Kurosawa, Mizuki× Abe, Manabu× Sakimura, Kenji× Fukai, Tomoki× Goda, Yukiko |
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書誌情報 |
en : eLife 巻 10, p. e70818, 発行日 2021-11-16 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experience-dependent plasticity is a key feature of brain synapses for which neuronal N-Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit refinement to learning and memory. Astrocytes also express NMDARs, although their exact function has remained controversial. Here, we identify in mouse hippocampus, a circuit function for GluN2C NMDAR, a subtype highly expressed in astrocytes, in layer-specific tuning of synaptic strengths in CA1 pyramidal neurons. Interfering with astrocyte NMDAR or GluN2C NMDAR activity reduces the range of presynaptic strength distribution specifically in the stratum radiatum inputs without an appreciable change in the mean presynaptic strength. Mathematical modeling shows that narrowing of the width of presynaptic release probability distribution compromises the expression of long-term synaptic plasticity. Our findings suggest a novel feedback signaling system that uses astrocyte GluN2C NMDARs to adjust basal synaptic weight distribution of Schaffer collateral inputs, which in turn impacts computations performed by the CA1 pyramidal neuron. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications, Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
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関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34693906 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.70818 | |||||
権利 | ||||||
権利情報 | © 2021 Chipman et al. | |||||
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識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/70818 | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |