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Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
https://oist.repo.nii.ac.jp/records/254
https://oist.repo.nii.ac.jp/records/254b036a7b2-83ab-47e1-b09c-3a6b37eec8a4
名前 / ファイル | ライセンス | アクション |
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Tumour-on-chip (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-19 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Tsai, Hsieh-Fu
× Tsai, Hsieh-Fu× Trubelja, Alen× Shen, Amy Q.× Bao, Gang |
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書誌情報 |
en : Journal of The Royal Society Interface 巻 14, 号 131, p. 20170137, 発行日 2017-06-21 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer remains one of the leading causes of death, albeit enormous efforts to cure the disease. To overcome the major challenges in cancer therapy, we need to have a better understanding of the tumour microenvironment (TME), as well as a more effective means to screen anti-cancer drug leads; both can be achieved using advanced technologies, including the emerging tumour-on-a-chip technology. Here, we review the recent development of the tumour-on-a-chip technology, which integrates microfluidics, microfabrication, tissue engineering and biomaterials research, and offers new opportunities for building and applying functional three-dimensional in vitro human tumour models for oncology research, immunotherapy studies and drug screening. In particular, tumour-on-a-chip microdevices allow well-controlled microscopic studies of the interaction among tumour cells, immune cells and cells in the TME, of which simple tissue cultures and animal models are not amenable to do. The challenges in developing the next-generation tumour-on-a-chip technology are also discussed. | |||||
出版者 | ||||||
出版者 | The Royal Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1742-5689 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1742-5662 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28637915 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1098/rsif.2017.0137 | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://rsif.royalsocietypublishing.org/content/14/131/20170137 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |