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How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders
https://oist.repo.nii.ac.jp/records/2728
https://oist.repo.nii.ac.jp/records/27287ab689ea-2350-420c-871a-5fd587d4ff49
名前 / ファイル | ライセンス | アクション |
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fnmol-15-893111_vor (2.5 MB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-08-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | potassium chloride cotransporter-2 (KCC2) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Na+-K+-2Cl− cotransporter-1 (NKCC1) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuropsychiatric disorders (NPD) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neurodevelopmental disorders (NDD) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chloride homeostasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GABA-shift | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Hui, Kelvin K.
× Hui, Kelvin K.× Chater, Thomas E.× Goda, Yukiko× Tanaka, Motomasa |
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書誌情報 |
en : Frontiers in Molecular Neuroscience 巻 15, p. 893111, 発行日 2022-07-08 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia. GABA neurotransmission, the principal inhibitory signal in the mature brain, is critically coupled to proper regulation of chloride homeostasis. During brain maturation, changes in the transport of chloride ions across neuronal cell membranes act to gradually change the majority of GABA signaling from excitatory to inhibitory for neuronal activation, and dysregulation of this GABA-shift likely contributes to multiple neurodevelopmental abnormalities that are associated with circuit dysfunction. Whilst traditionally viewed as a phenomenon which occurs during brain development, recent evidence suggests that this GABA-shift may also be involved in neuropsychiatric disorders due to the “dematuration” of affected neurons. In this review, we will discuss the cell signaling and regulatory mechanisms underlying the GABA-shift phenomenon in the context of the latest findings in the field, in particular the role of chloride cotransporters NKCC1 and KCC2, and furthermore how these regulatory processes are altered in neurodevelopmental and neuropsychiatric disorders. We will also explore the interactions between GABAergic interneurons and other cell types in the developing brain that may influence the GABA-shift. Finally, with a greater understanding of how the GABA-shift is altered in pathological conditions, we will briefly outline recent progress on targeting NKCC1 and KCC2 as a therapeutic strategy against neurodevelopmental and neuropsychiatric disorders associated with improper chloride homeostasis and GABA-shift abnormalities. | |||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1662-5099 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/35875665 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fnmol.2022.893111 | |||||
権利 | ||||||
権利情報 | © 2022 Hui, Chater, Goda and Tanaka. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fnmol.2022.893111/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |