WEKO3
アイテム
{"_buckets": {"deposit": "cdc9889d-49ce-4304-b08d-525e3eff1729"}, "_deposit": {"created_by": 26, "id": "437", "owners": [26], "pid": {"revision_id": 0, "type": "depid", "value": "437"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00000437", "sets": ["25"]}, "author_link": ["1782", "1783", "1786", "1785", "1784", "1781", "1789", "1788", "1787"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-09-21", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageStart": "e1005754", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{}, {"bibliographic_title": "PLoS Computational Biology", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sudhakar, Shyam Kumar"}], "nameIdentifiers": [{"nameIdentifier": "1781", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hong, Sungho"}], "nameIdentifiers": [{"nameIdentifier": "1782", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Raikov, Ivan"}], "nameIdentifiers": [{"nameIdentifier": "1783", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Publio, Rodrigo"}], "nameIdentifiers": [{"nameIdentifier": "1784", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lang, Claus"}], "nameIdentifiers": [{"nameIdentifier": "1785", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Close, Thomas"}], "nameIdentifiers": [{"nameIdentifier": "1786", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Guo, Daqing"}], "nameIdentifiers": [{"nameIdentifier": "1787", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Negrello, Mario"}], "nameIdentifiers": [{"nameIdentifier": "1788", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "De Schutter, Erik"}], "nameIdentifiers": [{"nameIdentifier": "1789", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns. To study its dynamics at multiple time scales in response to inputs approximating real spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer. Patterned mossy fiber activity induces rhythmic Golgi cell activity that is synchronized by shared parallel fiber input and by gap junctions. This leads to long distance synchrony of Golgi cells along the transverse axis, powerfully regulating granule cell firing by imposing inhibition during a specific time window. The essential network mechanisms, including tunable Golgi cell oscillations, on-beam inhibition and NMDA receptors causing first winner keeps winning of granule cells, illustrate how fundamental properties of the granule layer operate in tandem to produce (1) well timed and spatially bound output, (2) a wide dynamic range of granule cell firing and (3) transient and coherent gating oscillations. These results substantially enrich our understanding of granule cell layer processing, which seems to promote spatial group selection of granule cell activity as a function of timing of mossy fiber input.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Public Library of Science"}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/28934196", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1371/journal.pcbi.1005754", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005754", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2017 Sudhakar et al."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1553-7358", "subitem_source_identifier_type": "ISSN"}, {"subitem_source_identifier": "1553-734X ", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-07-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "journal.pcbi.1005754.pdf", "filesize": [{"value": "12.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution 4.0 International\n(http://creativecommons.org/licenses/by/4.0/) ", "licensetype": "license_free", "mimetype": "application/pdf", "size": 12900000.0, "url": {"label": "journal.pcbi.1005754", "url": "https://oist.repo.nii.ac.jp/record/437/files/journal.pcbi.1005754.pdf"}, "version_id": "8bbf612b-8118-44c8-9508-4e8aad079917"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "26", "path": ["25"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/437", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-07-23"}, "publish_date": "2018-07-23", "publish_status": "0", "recid": "437", "relation": {}, "relation_version_is_last": true, "title": ["Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer"], "weko_shared_id": 26}
Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer
https://oist.repo.nii.ac.jp/records/437
https://oist.repo.nii.ac.jp/records/43785c2dbdd-030e-4179-b900-b838485a50f8
名前 / ファイル | ライセンス | アクション |
---|---|---|
journal.pcbi.1005754 (12.9 MB)
|
Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-07-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Sudhakar, Shyam Kumar
× Sudhakar, Shyam Kumar× Hong, Sungho× Raikov, Ivan× Publio, Rodrigo× Lang, Claus× Close, Thomas× Guo, Daqing× Negrello, Mario× De Schutter, Erik |
|||||
書誌情報 |
en : PLoS Computational Biology 巻 13, 号 9, p. e1005754, 発行日 2017-09-21 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns. To study its dynamics at multiple time scales in response to inputs approximating real spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer. Patterned mossy fiber activity induces rhythmic Golgi cell activity that is synchronized by shared parallel fiber input and by gap junctions. This leads to long distance synchrony of Golgi cells along the transverse axis, powerfully regulating granule cell firing by imposing inhibition during a specific time window. The essential network mechanisms, including tunable Golgi cell oscillations, on-beam inhibition and NMDA receptors causing first winner keeps winning of granule cells, illustrate how fundamental properties of the granule layer operate in tandem to produce (1) well timed and spatially bound output, (2) a wide dynamic range of granule cell firing and (3) transient and coherent gating oscillations. These results substantially enrich our understanding of granule cell layer processing, which seems to promote spatial group selection of granule cell activity as a function of timing of mossy fiber input. | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1553-7358 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1553-734X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28934196 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1371/journal.pcbi.1005754 | |||||
権利 | ||||||
権利情報 | © 2017 Sudhakar et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005754 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |