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Using synthetic biology to study gene regulatory evolution
https://oist.repo.nii.ac.jp/records/446
https://oist.repo.nii.ac.jp/records/44661804d25-b134-40a0-9aeb-82866fd19d1e
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S0959437X1730014X-main (2.3 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-07-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Using synthetic biology to study gene regulatory evolution | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Crocker, Justin
× Crocker, Justin× Ilsley, Garth R |
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書誌情報 |
en : Current Opinion in Genetics & Development 巻 47, p. 91-101, 発行日 2017-09-29 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Transcriptional enhancers specify the precise time, level, and location of gene expression. Disentangling and characterizing the components of enhancer activity in multicellular eukaryotic development has proven challenging because enhancers contain activator and repressor binding sites for multiple factors that each exert nuanced, context-dependent control of enhancer activity. Recent advances in synthetic biology provide an almost unlimited ability to create and modify regulatory elements and networks, offering unprecedented power to study gene regulation. Here we review several studies demonstrating the utility of synthetic biology for studying enhancer function during development and evolution. These studies clearly show that synthetic biology can provide a way to reverse-engineer and reengineer transcriptional regulation in animal genomes with enormous potential for understanding evolution. | |||||
出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0959-437X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28968519 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.gde.2017.09.001 | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0959437X1730014X?via%3Dihub#sec0040 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |