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Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience
https://oist.repo.nii.ac.jp/records/749
https://oist.repo.nii.ac.jp/records/7496d0bec27-7e2e-45a0-9b87-0e7067e0daff
名前 / ファイル | ライセンス | アクション |
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Miyazaki-2018-Reward probability and timing un (6.2 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-11-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Miyazaki, Katsuhiko
× Miyazaki, Katsuhiko× Miyazaki, Kayoko W.× Yamanaka, Akihiro× Tokuda, Tomoki× Tanaka, Kenji F.× Doya, Kenji |
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書誌情報 |
en : Nature Communications 巻 9, p. 2048, 発行日 2018-06-01 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Recent experiments have shown that optogenetic activation of serotonin neurons in the dorsal raphe nucleus (DRN) in mice enhances patience in waiting for future rewards. Here, we show that serotonin effect in promoting waiting is maximized by both high probability and high timing uncertainty of reward. Optogenetic activation of serotonergic neurons prolongs waiting time in no-reward trials in a task with 75% food reward probability, but not with 50 or 25% reward probabilities. Serotonin effect in promoting waiting increases when the timing of reward presentation becomes unpredictable. To coherently explain the experimental data, we propose a Bayesian decision model of waiting that assumes that serotonin neuron activation increases the prior probability or subjective confidence of reward delivery. The present data and modeling point to the possibility of a generalized role of serotonin in resolving trade-offs, not only between immediate and delayed rewards, but also between sensory evidence and subjective confidence. | |||||
出版者 | ||||||
出版者 | Nature Communications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29858574 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-018-04496-y | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-018-04496-y#Abs1 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |