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Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus
https://oist.repo.nii.ac.jp/records/1785
https://oist.repo.nii.ac.jp/records/17855e79880e-1ec4-4233-899e-618215ca123b
名前 / ファイル | ライセンス | アクション |
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jgv001491 (3.8 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | coronavirus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | SARS-CoV-2 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | MERS-CoV | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | recombination | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | emergence | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | predictions | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | COVID-19 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Banerjee, Arinjay
× Banerjee, Arinjay× Doxey, Andrew C.× Tremblay, Benjamin J.-M.× Mansfield, Michael J.× Subudhi, Sonu× Hirota, Jeremy A.× Miller, Matthew S.× McArthur, Andrew G.× Mubareka, Samira× Mossman, Karen |
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書誌情報 |
en : Journal of General Virology p. 001491, 発行日 2020-09-09 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein–receptor interacting residues. In conclusion, we suggest that a recombination between SARS-CoV-2 and MERS-CoV RNA is possible and urge public health laboratories in high-risk areas to develop diagnostic capability for the detection of recombined coronaviruses in patient samples. | |||||
出版者 | ||||||
出版者 | Microbiology Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-1317 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1465-2099 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32902372 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1099/jgv.0.001491 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001491 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |