WEKO3
Item
Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking
https://oist.repo.nii.ac.jp/records/1170
https://oist.repo.nii.ac.jp/records/1170e02a97ea-3a3e-40db-bef7-250d56a1fca7
| Name / File | License | Actions |
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Neuroscience Montrose revision (clear copy)_with CC-BY-NC-ND license (915.0 kB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/Licenses/by-nc-nd/4.0/)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| PubDate | 2020-02-10 | |||||||||||||
| Title | ||||||||||||||
| Title | Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking | |||||||||||||
| Language | en | |||||||||||||
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| Language | eng | |||||||||||||
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| Resource Type Identifier | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| Resource Type | journal article | |||||||||||||
| Author |
Montrose, Kristopher
× Montrose, Kristopher
× Kobayashi, Shizuka
× Manabe, Toshiya
× Yamamoto, Tadashi
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| Bibliographic Information |
en : Neuroscience Volume Number 414, p. 154-167, Issue Date 2019-07-13 |
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| Abstract | ||||||||||||||
| Description Type | Other | |||||||||||||
| Description | Accumulating evidence suggests that glutamatergic signaling and synaptic plasticity underlie one of a number of ways psychiatric disorders appear. The present study reveals a possible mechanism by which this occurs, through highlighting the importance of LMTK3, in the brain. Behavioral analysis of Lmtk3-KO mice revealed a number of abnormalities that have been linked to psychiatric disease such as hyper-sociability, PPI deficits and cognitive dysfunction. Treatment with clozapine suppressed these behavioral changes in Lmtk3-KO mice. As synaptic dysfunction is implicated in human psychiatric disease, we analyzed the LTP of Lmtk3-KO mice and found that induction is severely impaired. Further investigation revealed abnormalities in GluA1 trafficking after AMPA stimulation in Lmtk3-KO neurons, along with a reduction in GluA1 expression in the post-synaptic density. Therefore, we hypothesize that LMTK3 is an important factor involved in the trafficking of GluA1 during LTP, and that disruption of this pathway contributes to the appearance of behavior associated with human psychiatric disease in mice. | |||||||||||||
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| Source Identifier Type | ISSN | |||||||||||||
| Source Identifier | 0306-4522 | |||||||||||||
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| Source Identifier Type | ISSN | |||||||||||||
| Source Identifier | 1873-7544 | |||||||||||||
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| Relation Type | isVersionOf | |||||||||||||
| Identifier Type | PMID | |||||||||||||
| Related Identifier | info:pmid/31310731 | |||||||||||||
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| Relation Type | isVersionOf | |||||||||||||
| Identifier Type | DOI | |||||||||||||
| Related Identifier | info:doi/10.1016/j.neuroscience.2019.06.033 | |||||||||||||
| Rights | ||||||||||||||
| Rights | © 2019 IBRO. Published by Elsevier Ltd. | |||||||||||||
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| Related Title | http://creativecommons.org/Licenses/by-nc-nd/4.0/ | |||||||||||||
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| Identifier Type | URI | |||||||||||||
| Related Identifier | https://www.sciencedirect.com/science/article/pii/S0306452219304506 | |||||||||||||
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| Version Type | AM | |||||||||||||
| Version Type Resource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
