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Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking
https://oist.repo.nii.ac.jp/records/1170
https://oist.repo.nii.ac.jp/records/1170e02a97ea-3a3e-40db-bef7-250d56a1fca7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Neuroscience Montrose revision (clear copy)_with CC-BY-NC-ND license (915.0 kB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/Licenses/by-nc-nd/4.0/)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-02-10 | |||||
| タイトル | ||||||
| タイトル | Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Montrose, Kristopher
× Montrose, Kristopher× Kobayashi, Shizuka× Manabe, Toshiya× Yamamoto, Tadashi |
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| 書誌情報 |
en : Neuroscience 巻 414, p. 154-167, 発行日 2019-07-13 |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Accumulating evidence suggests that glutamatergic signaling and synaptic plasticity underlie one of a number of ways psychiatric disorders appear. The present study reveals a possible mechanism by which this occurs, through highlighting the importance of LMTK3, in the brain. Behavioral analysis of Lmtk3-KO mice revealed a number of abnormalities that have been linked to psychiatric disease such as hyper-sociability, PPI deficits and cognitive dysfunction. Treatment with clozapine suppressed these behavioral changes in Lmtk3-KO mice. As synaptic dysfunction is implicated in human psychiatric disease, we analyzed the LTP of Lmtk3-KO mice and found that induction is severely impaired. Further investigation revealed abnormalities in GluA1 trafficking after AMPA stimulation in Lmtk3-KO neurons, along with a reduction in GluA1 expression in the post-synaptic density. Therefore, we hypothesize that LMTK3 is an important factor involved in the trafficking of GluA1 during LTP, and that disruption of this pathway contributes to the appearance of behavior associated with human psychiatric disease in mice. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0306-4522 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1873-7544 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/31310731 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.neuroscience.2019.06.033 | |||||
| 権利 | ||||||
| 権利情報 | © 2019 IBRO. Published by Elsevier Ltd. | |||||
| 情報源 | ||||||
| 関連名称 | http://creativecommons.org/Licenses/by-nc-nd/4.0/ | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0306452219304506 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
