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Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes
https://oist.repo.nii.ac.jp/records/1540
https://oist.repo.nii.ac.jp/records/1540ce6cf68e-9742-46a5-9639-59a6abe814a9
名前 / ファイル | ライセンス | アクション |
---|---|---|
Mackay-2019-Dynamic control of neurochemical r (2.5 MB)
|
Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-06-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Mackay, Sean M.
× Mackay, Sean M.× Myint, David Mo Aung× Easingwood, Richard A.× Hegh, Dylan Y.× Wickens, Jeffery R.× Hyland, Brian I.× Jameson, Guy N. L.× Reynolds, John N. J.× Tan, Eng Wui |
|||||
書誌情報 |
en : Communications Chemistry 巻 2, p. 122, 発行日 2019-10-25 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The unique surface plasmon resonance of hollow gold nanoshells can be used to achieve drug release from liposomes upon laser stimulation, and adapted to mimic the intricate dynamics of neurotransmission ex vivo in brain preparations. However, to induce a physiological response in vivo requires the degree of temporal precision afforded by laser stimulation, but with a greater depth of penetration through tissue. Here we report that the attachment of hollow gold nanoshells to the surface of robust liposomes results in a construct that is highly sensitive to ultrasonic stimulation. The resulting construct can be remotely triggered by low intensity, therapeutic ultrasound. To our knowledge, this is the first example of nanoparticle-liposome system that can be activated by both laser and acoustic stimulation. The system is capable of encapsulating the neurochemical dopamine, and repeatedly releasing small amounts on-demand in a circulating environment, allowing for precise spatiotemporal control over the release profile. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2399-3669 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s42004-019-0226-0 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s42004-019-0226-0 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |