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A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans
https://oist.repo.nii.ac.jp/records/1777
https://oist.repo.nii.ac.jp/records/1777c57cc6e7-f037-499c-8df2-fe3fc544a859
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S0960982220308617-main (1.4 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neanderthals | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | sodium channel | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | pain | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | introgression | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gene flow | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zeberg, Hugo
× Zeberg, Hugo× Dannemann, Michael× Sahlholm, Kristoffer× Tsuo, Kristin× Maricic, Tomislav× Wiebe, Victor× Hevers, Wulf× Robinson, Hugh P.C.× Kelso, Janet× Pääbo, Svante |
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書誌情報 |
en : Current Biology 巻 30, 号 17, p. 3465-3469.e4, 発行日 2020-09-07 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) relative to modern humans. We expressed Nav1.7 proteins carrying all combinations of these substitutions and studied their electrophysiological effects. Whereas the single amino acid substitutions do not affect the function of the ion channel, the full Neanderthal variant carrying all three substitutions, as well as the combination of V991L with D1908G, shows reduced inactivation, suggesting that peripheral nerves were more sensitive to painful stimuli in Neanderthals than in modern humans. We show that, due to gene flow from Neanderthals, the three Neanderthal substitutions are found in approximately 0.4% of present-day Britons, where they are associated with heightened pain sensitivity. | |||||
出版者 | ||||||
出版者 | Elsevier Inc | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0960-9822 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1879-0445 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32707058 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.cub.2020.06.045 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0960982220308617?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |