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Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms
https://oist.repo.nii.ac.jp/records/2603
https://oist.repo.nii.ac.jp/records/2603b91b8684-b3c1-4bea-8630-88c6ca49b28f
名前 / ファイル | ライセンス | アクション |
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Xu-2022-Inhibitory Neurotransmission Is Sex-De (3.3 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-03-24 | |||||
タイトル | ||||||
タイトル | Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endocannabinoids | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neuroHIV | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fatty acid amide hydrolase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Tat transgenic mice | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | inhibitory postsynaptic potentials | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | PF3845 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cannabinoid type 1 receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anandamide | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | non-eCB lipids | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endocannabinoid enzyme inhibitor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Xu, Changqing
× Xu, Changqing× Yadav-Samudrala, Barkha J.× Xu, Callie× Nath, Bhupendra× Mistry, Twisha× Jiang, Wei× Niphakis, Micah J.× Cravatt, Benjamin F.× Mukhopadhyay, Somnath× Lichtman, Aron H.× Ignatowska-Jankowska, Bogna M.× Fitting, Sylvia |
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書誌情報 |
en : Cells 巻 11, 号 5, p. 857, 発行日 2022-03-02 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | (1) Background. The endocannabinoid (eCB) system, which regulates physiological and cognitive processes, presents a promising therapeutic target for treating HIV-associated neurocognitive disorders (HAND). Here we examine whether upregulating eCB tone has potential protective effects against HIV-1 Tat (a key HIV transactivator of transcription) protein-induced alterations in synaptic activity. (2) Methods. Whole-cell patch-clamp recordings were performed to assess inhibitory GABAergic neurotransmission in prefrontal cortex slices of Tat transgenic male and female mice, in the presence and absence of the fatty acid amide hydrolase (FAAH) enzyme inhibitor PF3845. Western blot and mass spectrometry analyses assessed alterations of cannabinoid receptor and enzyme protein expression as well as endogenous ligands, respectively, to determine the impact of Tat exposure on the eCB system. (3) Results. GABAergic activity was significantly altered upon Tat exposure based on sex, whereas the effectiveness of PF3845 to suppress GABAergic activity in Tat transgenic mice was not altered by Tat or sex and involved CB₁R-related mechanisms that depended on calcium signaling. Additionally, our data indicated sex-dependent changes for AEA and related non-eCB lipids based on Tat induction. (4) Conclusion. Results highlight sex- and/or Tat-dependent alterations of GABAergic activity and eCB signaling in the prefrontal cortex of Tat transgenic mice and further increase our understanding about the role of FAAH inhibition in neuroHIV. | |||||
出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2073-4409 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/35269478 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3390/cells11050857 | |||||
権利 | ||||||
権利情報 | © 2022 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.mdpi.com/2073-4409/11/5/857 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |