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Population genetics in microchannels
https://oist.repo.nii.ac.jp/records/2612
https://oist.repo.nii.ac.jp/records/2612b5031f1d-c9c8-41a8-b6bc-794ec46d2812
名前 / ファイル | ライセンス | アクション |
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pna-oa_2 (1.5 MB)
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CC BY-NC-ND 4.0
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Population genetics in microchannels | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spatial population dynamics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bacterial evolution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microfluidics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | individual-based models | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Koldaeva, Anzhelika
× Koldaeva, Anzhelika× Tsai, Hsieh-Fu× Shen, Amy Q.× Pigolotti, Simone |
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書誌情報 |
en : Proceedings of the National Academy of Sciences 巻 119, 号 12, p. e2120821119, 発行日 2022-03-18 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Spatial constraints, such as rigid barriers, affect the dynamics of cell populations, potentially altering the course of natural evolution. In this paper, we investigate the population genetics of Escherichia coli proliferating in microchannels with open ends. Our analysis is based on a population model, in which reproducing cells shift entire lanes of cells toward the open ends of the channel. The model predicts that diversity is lost very rapidly within lanes but at a much slower pace among lanes. As a consequence, two mixed, neutral E. coli strains competing in a microchannel must organize into an ordered regular stripe pattern in the course of a few generations. These predictions are in quantitative agreement with our experiments. We also demonstrate that random mutations appearing in the middle of the channel are much more likely to reach fixation than those occurring elsewhere. Our results illustrate fundamental mechanisms of microbial evolution in spatially confined space. | |||||
出版者 | ||||||
出版者 | National Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-8424 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1091-6490 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/35302890 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1073/pnas.2120821119 | |||||
権利 | ||||||
権利情報 | © 2022 the Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.pnas.org/doi/full/10.1073/pnas.2120821119 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |