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The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum
https://oist.repo.nii.ac.jp/records/2679
https://oist.repo.nii.ac.jp/records/26793ae83582-4f28-4753-a268-2492c4683195
名前 / ファイル | ライセンス | アクション |
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7831.full (6.1 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | GABA | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lateral inhibition | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | MSN | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | serotonin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | SPN | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | synapse | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Pommer, Stefan
× Pommer, Stefan× Akamine, Yumiko× Schiffmann, Serge N.× de Kerchove d'Exaerde, Alban× Wickens, Jeffery R. |
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書誌情報 |
en : The Journal of Neuroscience 巻 41, 号 37, p. 7831-7847, 発行日 2021-09-15 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main axon, forming a local lateral inhibition network. Serotonin, acting via the 5-HT1B receptor, modulates neurotransmitter release from SPN terminals in striatal output nuclei, but the role of 5-HT1B receptors in lateral inhibition among SPNs in the striatum is unknown. Here, we report the effects of 5-HT1B receptor activation on lateral inhibition in the mouse striatum. Whole-cell recordings were made from SPNs in acute brain slices of either sex, while optogenetically activating presynaptic SPNs or fast-spiking interneurons (FSIs). Activation of 5-HT1B receptors significantly reduced the amplitude of IPSCs evoked by optical stimulation of both direct and indirect pathway SPNs. This reduction was blocked by application of a 5-HT1B receptor antagonist. Activation of 5-HT1B receptors did not reduce the amplitude of IPSCs evoked from FSIs. These results suggest a new role for serotonin as a modulator of lateral inhibition among striatal SPNs. The 5-HT1B receptor may, therefore, be a suitable target for future behavioral experiments investigating the currently unknown role of lateral inhibition in the function of the striatum. | |||||
出版者 | ||||||
出版者 | Society for Neuroscience | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1529-2401 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0270-6474 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34348999 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1523/JNEUROSCI.1037-20.2021 | |||||
権利 | ||||||
権利情報 | © 2021 Pommer et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jneurosci.org/content/41/37/7831 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |