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Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish
https://oist.repo.nii.ac.jp/records/936
https://oist.repo.nii.ac.jp/records/936037d33e4-0411-4130-8cd4-f5f2d1836c05
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Mochizuki-2018-Endocytic trafficking factor VP (14.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-06-13 | |||||
| タイトル | ||||||
| タイトル | Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Mochizuki, Toshiaki
× Mochizuki, Toshiaki× Kojima, Yutaka× Nishiwaki, Yuko× Harakuni, Tetsuya× Masai, Ichiro |
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| 書誌情報 |
en : Development 巻 145, 号 20, p. dev170282, 発行日 2018-10-15 |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In vertebrate lens, lens epithelial cells cover the anterior half of the lens fiber core. Lens epithelial cells proliferate, move posteriorly and start to differentiate into lens fiber cells at the lens equator. Although FGF signaling promotes this equatorial commencement of lens fiber differentiation, the underlying mechanism is not fully understood. Here, we show that lens epithelial cells abnormally enter lens fiber differentiation without passing through the equator in zebrafish vps45 mutants. VPS45 belongs to the Sec1/Munc18-like protein family and promotes endosome trafficking, which differentially modulates signal transduction. Ectopic lens fiber differentiation in vps45 mutants does not depend on FGF, but is mediated through activation of TGFbeta signaling and inhibition of canonical Wnt signaling. Thus, VPS45 normally suppresses lens fiber differentiation in the anterior region of lens epithelium by modulating TGFbeta and canonical Wnt signaling pathways. These data indicate a novel role of endosome trafficking to ensure equator-dependent commencement of lens fiber differentiation. | |||||
| 出版者 | ||||||
| 出版者 | Company of Biologists Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0950-1991 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1477-9129 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/30322969 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1242/dev.170282 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 The Company of Biologists Ltd. | |||||
| 情報源 | ||||||
| 関連名称 | https://creativecommons.org/licenses/by/3.0/ | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://dev.biologists.org/content/145/20/dev170282 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
