WEKO3
アイテム
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Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes
https://oist.repo.nii.ac.jp/records/1007
https://oist.repo.nii.ac.jp/records/10076849074c-335a-45fc-892a-4ff00f7e6e28
名前 / ファイル | ライセンス | アクション |
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Suzuki-2019-Postnatal liver functional maturat (14.9 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Suzuki, Toru
× Suzuki, Toru× Kikuguchi, Chisato× Nishijima, Saori× Nagashima, Takeshi× Takahashi, Akinori× Okada, Mariko× Yamamoto, Tadashi |
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書誌情報 |
en : Development 巻 146, 号 4, p. dev168146, 発行日 2019-02-15 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Liver development involves dramatic gene expression changes mediated by transcriptional and post-transcriptional control. Here, we show that the Cnot deadenylase complex plays a crucial role in liver functional maturation. The Cnot3 gene encodes an essential subunit of the Cnot complex. Mice lacking Cnot3 in liver have reduced body and liver masses, and they display anemia and severe liver damage. Histological analyses indicate that Cnot3-deficient (Cnot3(-/-) ) hepatocytes are irregular in size and morphology, resulting in formation of abnormal sinusoids. We observe hepatocyte death, increased abundance of mitotic and mononucleate hepatocytes, and inflammation. Cnot3(-/-) livers show increased expression of immune response-related, cell cycle-regulating and immature liver genes, while many genes relevant to liver functions, such as oxidation-reduction, lipid metabolism and mitochondrial function, decrease, indicating impaired liver functional maturation. Highly expressed mRNAs possess elongated poly(A) tails and are stabilized in Cnot3(-/-) livers, concomitant with an increase of the proteins they encode. In contrast, transcription of liver function-related mRNAs was lower in Cnot3(-/-) livers. We detect efficient suppression of Cnot3 protein postnatally, demonstrating the crucial contribution of mRNA decay to postnatal liver functional maturation. | |||||
出版者 | ||||||
出版者 | The Company of Biologists Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0950-1991 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1477-9129 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30733279 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1242/dev.168146 | |||||
権利 | ||||||
権利情報 | © 2019 The Company of Biologists Ltd. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://dev.biologists.org/content/146/4/dev168146 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |