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Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan
https://oist.repo.nii.ac.jp/records/1118
https://oist.repo.nii.ac.jp/records/1118ca1afe60-8739-4f85-89ff-c08e1707ac85
名前 / ファイル | ライセンス | アクション |
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Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-10-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kawamura, Kazuto
× Kawamura, Kazuto× Maruyama, Ichiro N. |
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書誌情報 |
en : G3: Genes, Genomes, Genetics 巻 9, 号 8, p. 2415-2423, 発行日 2019-06-18 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Two people with the same lifespan do not necessarily have the same healthspan. One person may retain locomotor and cognitive abilities until the end of life, while another person may lose them during adulthood. Unbiased searches for genes that are required to maintain locomotor ability during adulthood may uncover key regulators of locomotor healthspan. Here, we take advantage of the relatively short lifespan of the nematode Caenorhabditis elegans and develop a novel screening procedure to collect mutants with locomotor deficits that become apparent in adulthood. After ethyl methanesulfonate mutagenesis, we isolated five C. elegans mutant strains that progressively lose adult locomotor ability. In one of the mutant strains, a nonsense mutation in elpc-2, which encodes Elongator Complex Protein Component 2, causes a progressive decline in locomotor ability during adulthood. Mutants and mutations identified in the present screen may provide insights into mechanisms of age-related locomotor impairment and the maintenance of locomotor healthspan. | |||||
出版者 | ||||||
出版者 | Genetics Society of America | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2160-1836 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31213517 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1534/g3.119.400241 | |||||
権利 | ||||||
権利情報 | © 2019 Kawamura, Maruyama | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.g3journal.org/content/9/8/2415 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |