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We find that KLK1s have been independently coopted into the venom of shrews and solenodons following their divergence during the late Cretaceous, suggesting that evolutionary constraints may be acting on these genes. 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Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals
https://oist.repo.nii.ac.jp/records/1230
https://oist.repo.nii.ac.jp/records/1230d6b72a39-9bbc-4b1d-bb2b-6c2f1654266f
名前 / ファイル | ライセンス | アクション |
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Casewell, Nicholas R.
× Casewell, Nicholas R.× Petras, Daniel× Card, Daren C.× Suranse, Vivek× Mychajliw, Alexis M.× Richards, David× Koludarov, Ivan× Albulescu, Laura-Oana× Slagboom, Julien× Hempel, Benjamin-Florian× Ngum, Neville M.× Kennerley, Rosalind J.× Brocca, Jorge L.× Whiteley, Gareth× Harrison, Robert A.× Bolton, Fiona M. S.× Debono, Jordan× Vonk, Freek J.× Alföldi, Jessica× Johnson, Jeremy× Karlsson, Elinor K.× Lindblad-Toh, Kerstin× Mellor, Ian R.× Süssmuth, Roderich D.× Fry, Bryan G.× Kuruppu, Sanjaya× Hodgson, Wayne C.× Kool, Jeroen× Castoe, Todd A.× Barnes, Ian× Sunagar, Kartik× Undheim, Eivind A. B.× Turvey, Samuel T. |
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書誌情報 |
en : Proceedings of the National Academy of Sciences 巻 116, 号 51, p. 25745-25755, 発行日 2019-11-26 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Venom systems are key adaptations that have evolved throughout the tree of life and typically facilitate predation or defense. Despite venoms being model systems for studying a variety of evolutionary and physiological processes, many taxonomic groups remain understudied, including venomous mammals. Within the order Eulipotyphla, multiple shrew species and solenodons have oral venom systems. Despite morphological variation of their delivery systems, it remains unclear whether venom represents the ancestral state in this group or is the result of multiple independent origins. We investigated the origin and evolution of venom in eulipotyphlans by characterizing the venom system of the endangered Hispaniolan solenodon (Solenodon paradoxus). We constructed a genome to underpin proteomic identifications of solenodon venom toxins, before undertaking evolutionary analyses of those constituents, and functional assessments of the secreted venom. Our findings show that solenodon venom consists of multiple paralogous kallikrein 1 (KLK1) serine proteases, which cause hypotensive effects in vivo, and seem likely to have evolved to facilitate vertebrate prey capture. Comparative analyses provide convincing evidence that the oral venom systems of solenodons and shrews have evolved convergently, with the 4 independent origins of venom in eulipotyphlans outnumbering all other venom origins in mammals. We find that KLK1s have been independently coopted into the venom of shrews and solenodons following their divergence during the late Cretaceous, suggesting that evolutionary constraints may be acting on these genes. Consequently, our findings represent a striking example of convergent molecular evolution and demonstrate that distinct structural backgrounds can yield equivalent functions. | |||||
出版者 | ||||||
出版者 | National Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-8424 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1091-6490 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31772017 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1073/pnas.1906117116 | |||||
権利 | ||||||
権利情報 | © 2019 the Author(s) | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.pnas.org/content/116/51/25745 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |