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Methylphenidate modifies reward cue responses in adults with ADHD: An fMRI study
https://oist.repo.nii.ac.jp/records/1482
https://oist.repo.nii.ac.jp/records/1482564bdabd-ce88-43ef-83c5-3f685ea7e527
名前 / ファイル | ライセンス | アクション |
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Furukawa-2020-Methylphenidate modifies reward (1.5 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-05-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Methylphenidate modifies reward cue responses in adults with ADHD: An fMRI study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Furukawa, Emi
× Furukawa, Emi× da Costa, Raquel Quimas Molina× Bado, Patricia× Hoefle, Sebastian× Vigne, Paula× Monteiro, Myriam× Wickens, Jeff R.× Moll, Jorge× Tripp, Gail× Mattos, Paulo |
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書誌情報 |
en : Neuropharmacology 巻 162, p. 107833, 発行日 2019-11-02 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Attention deficit hyperactivity disorder (ADHD) has been associated with neural hyposensitivity to reward-predicting cues. Methylphenidate is widely used in the management of the disorder's symptoms, but its effects on reward sensitivity in ADHD are unknown. The current study used fMRI to measure striatal responses to reward-predicting cues in adults with ADHD on and off methylphenidate and a control group, during a classical conditioning task. Responses to cued reward were also explored. Larger differences in the ventral striatum activation to reward cues versus non-reward cues were observed when the ADHD participants were on methylphenidate compared to placebo. In response to cued-reward outcome, an exploratory analysis showed methylphenidate reduced the BOLD time-series correlation between the dorsal striatum and dorsal medial prefrontal cortex. Methylphenidate's therapeutic effects may be mediated by altering reward processing in individuals with ADHD. | |||||
出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0028-3908 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1873-7064 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31689423 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.neuropharm.2019.107833 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s) | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0028390819303995 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |