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A model-based prediction of the calcium responses in the striatal synaptic spines depending on the timing of cortical and dopaminergic inputs and post-synaptic spikes
https://oist.repo.nii.ac.jp/records/1573
https://oist.repo.nii.ac.jp/records/1573dfef9b57-0d54-4bfa-b7e2-6846522c8373
名前 / ファイル | ライセンス | アクション |
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fncom-07-00119 (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A model-based prediction of the calcium responses in the striatal synaptic spines depending on the timing of cortical and dopaminergic inputs and post-synaptic spikes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Nakano, Takashi
× Nakano, Takashi× Yoshimoto, Junichiro× Doya, Kenji |
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書誌情報 |
en : Frontiers in Computational Neuroscience 巻 7, p. 119, 発行日 2013-09-13 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The dopamine-dependent plasticity of the cortico-striatal synapses is considered as the cellular mechanism crucial for reinforcement learning. The dopaminergic inputs and the calcium responses affect the synaptic plasticity by way of the signaling cascades within the synaptic spines. The calcium concentration within synaptic spines, however, is dependent on multiple factors including the calcium influx through ionotropic glutamate receptors, the intracellular calcium release by activation of metabotropic glutamate receptors, and the opening of calcium channels by EPSPs and back-propagating action potentials. Furthermore, dopamine is known to modulate the efficacies of NMDA receptors, some of the calcium channels, and sodium and potassium channels that affect the back propagation of action potentials. Here we construct an electric compartment model of the striatal medium spiny neuron with a realistic morphology and predict the calcium responses in the synaptic spines with variable timings of the glutamatergic and dopaminergic inputs and the postsynaptic action potentials. The model was validated by reproducing the responses to current inputs and could predict the electric and calcium responses to glutamatergic inputs and back-propagating action potential in the proximal and distal synaptic spines during up- and down-states. We investigated the calcium responses by systematically varying the timings of the glutamatergic and dopaminergic inputs relative to the action potential and found that the calcium response and the subsequent synaptic potentiation is maximal when the dopamine input precedes glutamate input and action potential. The prediction is not consistent with the hypothesis that the dopamine input provides the reward prediction error for reinforcement learning. The finding suggests that there is an unknown learning mechanisms at the network level or an unknown cellular mechanism for calcium dynamics and signaling cascades. | |||||
出版者 | ||||||
出版者 | Frontiers Media | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1662-5188 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/24062681 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fncom.2013.00119 | |||||
権利 | ||||||
権利情報 | © 2013 Nakano, Yoshimoto and Doya. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/3.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fncom.2013.00119/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |