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Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans
https://oist.repo.nii.ac.jp/records/1909
https://oist.repo.nii.ac.jp/records/19099daf2d6a-5a22-4feb-b273-918e1f48785c
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hda-3 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | age-related locomotor impairment | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | BATH domain | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | aging | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | longevity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kawamura, Kazuto
× Kawamura, Kazuto× Maruyama, Ichiro N. |
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書誌情報 |
en : Aging 巻 12, 号 23, p. 23525-23547, 発行日 2020-12-03 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Some genes are essential for survival, while other genes play modulatory roles on health and survival. Genes that play modulatory roles may promote an organism's survival and health by fine-tuning physiological processes. An unbiased search for genes that alter an organism's ability to maintain aspects of health may uncover modulators of lifespan and healthspan. From an unbiased screen for Caenorhabditis elegans mutants that show a progressive decline in motility, we aimed to identify genes that play a modulatory role in maintenance of locomotor healthspan. Here we report the involvement of hda-3, encoding a class I histone deacetylase, as a genetic factor that contributes in the maintenance of general health and locomotion in C. elegans. We identified a missense mutation in HDA-3 as the causative mutation in one of the isolated strains that show a progressive decline in maximum velocity and travel distance. From transcriptome analysis, we found a cluster of genes on Chromosome II carrying BATH domains that were downregulated by hda-3. Furthermore, downregulation of individual bath genes leads to significant decline in motility. Our study identifies genetic factors that modulate the maintenance of locomotor healthspan and may reveal potential targets for delaying age-related locomotor decline. | |||||
出版者 | ||||||
出版者 | Impact Journals | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1945-4589 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33276344 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.18632/aging.202296 | |||||
権利 | ||||||
権利情報 | © 2020 Kawamura and Maruyama. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.aging-us.com/article/202296/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |