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Enzymes and Liquid-Liquid Phase Separation: A New Era for the Regulation of Enzymatic Activity
https://oist.repo.nii.ac.jp/records/2000345
https://oist.repo.nii.ac.jp/records/2000345fccdf246-0b3a-4c38-b93b-8e5efdc7457f
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2024-01-16 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Enzymes and Liquid-Liquid Phase Separation: A New Era for the Regulation of Enzymatic Activity | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | enzyme | liquid-liquid phase separation | enzymatic activity | enzyme regulation | macromolecular crowding | cell metabolism | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者(英) |
DINDO, Mirco
× DINDO, Mirco
× BEVILACQUA, Alessandro
× LAURINO, Paola
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書誌情報 |
en : Seibutsu Butsuri 巻 63, 号 1, p. 12-15, 発行日 2023-03-25 |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Liquid-liquid phase separation (LLPS) is recognized as a mechanism for regulation of enzymatic activity. Biochemical mechanisms include concentrating reactants to enhance reaction rates or sequester enzymes and reactants from each other to reduce the reaction rate. On the other hand, LLPS might also regulate the diffusion of small molecules or important parameters for enzymatic activity (such as modulators, macromolecular crowding and changing the media physicochemical features) increasing or decreasing the reaction rate of the enzymes. Furthermore, the co-compartmentalization of specific enzymes can favour or speed up specific metabolic fluxes. Here, we discuss how LLPS contributed to generate a new era for enzyme regulation and the new possible subtle regulation mechanisms still unexplored. | |||||||||||
言語 | en | |||||||||||
出版者 | ||||||||||||
出版者 | The Biophysical Society of Japan | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 0582-4052 | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | EISSN | |||||||||||
収録物識別子 | 1347-4219 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.2142/biophys.63.12 | |||||||||||
権利 | ||||||||||||
権利情報 | © 2023 The Biophysical Society of Japan | |||||||||||
権利 | ||||||||||||
権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||
権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||||||
関連サイト | ||||||||||||
識別子タイプ | URI | |||||||||||
関連識別子 | https://doi.org/10.2142/biophys.63.12 | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |