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ダイニン軽鎖RB1はFMRPの軸索輸送と分解を制御する
https://doi.org/10.15102/0002000385
https://doi.org/10.15102/000200038519639b7a-1ee9-4af1-8987-f8301ef0a1cb
名前 / ファイル | ライセンス | アクション |
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AbdelaalSaraFulltext.pdf (4.7 MB)
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AbdelaalSaraExamAbstract.pdf (48 KB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2024-02-06 | |||||||
タイトル | ||||||||
言語 | ja | |||||||
タイトル | ダイニン軽鎖RB1はFMRPの軸索輸送と分解を制御する | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Dynein Light Chain Roadblock 1 Regulates FMRP Axonal Transport and Degradation | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
ID登録 | ||||||||
ID登録 | 10.15102/0002000385 | |||||||
ID登録タイプ | JaLC | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 (英) |
Abdelaal, Sara
× Abdelaal, Sara
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | The fragile X messenger ribonucleoprotein 1 (FMRP) is a multifunctional RNA binding protein (RBP) implicated in human neurodevelopmental and neurodegenerative disorders. FMRP mediates the localization and activitydependent translation of its associated mRNAs through the formation of phase separated condensates that are trafficked by microtubule-based motors in axons. Axonal transport and localized mRNA translation are critical processes for longterm neuronal survival and are closely linked to the pathogenesis of neurological diseases. FMRP dynein-mediated axonal trafficking is still largely unexplored, but likely to constitute a key process underlying FMRP spatiotemporal translational regulation. Here, we show that roadblock 1 (Dynlrb1), a subunit of the dynein complex, is a critical regulator of FMRP function in sensory neurons. In axons, FMRP associates with the dynein complex and is retrogradely trafficked in a Dynlrb1-dependent manner. Moreover, Dynlrb1 silencing induced FMRP granules accumulation and repressed the translation of Map1b, one of its primary mRNA targets. Our findings suggest that Dynlrb1 regulates FMRP function through the control of its transport and degradation. | |||||||
言語 | en | |||||||
口頭試問日 | ||||||||
2024-01-15 | ||||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2024-01-31 | |||||||
学位名 | ||||||||
学位名 | Doctor of Philosophy | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第138号 | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 38005 | |||||||
学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
権利 | ||||||||
権利情報 | © 2024 The Author. |