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連合運動学習時における小脳プルキンエ細胞の樹状突起の電圧シグナルについて
https://doi.org/10.15102/0002000698
https://doi.org/10.15102/0002000698ac1046d0-fe89-4d4a-b8ca-540e0e5d1cb3
| 名前 / ファイル | ライセンス | アクション |
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KoronfelLinaFulltext.pdf (160.9 MB)
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KoronfelLinaExamAbstract.pdf (48 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2024-11-20 | |||||||
| タイトル | ||||||||
| タイトル | 連合運動学習時における小脳プルキンエ細胞の樹状突起の電圧シグナルについて | |||||||
| 言語 | ja | |||||||
| タイトル | ||||||||
| タイトル | Dendritic Voltage Signaling in Cerebellar Purkinje Neurons during Associative Motor Learning | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Purkinje neuron physiology | Associative Motor Learning | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| ID登録 | ||||||||
| ID登録 | 10.15102/0002000698 | |||||||
| ID登録タイプ | JaLC | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 (英) |
Koronfel, Lina
× Koronfel, Lina
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The cerebellar cortex is critical for many forms of associative motor learning. Purkinje neurons (PNs), the sole output of the cerebellar cortex, arborize into massive dendritic trees allowing a wide range of possibilities for integration of input signals to produce an instructive output to downstream neurons. The output pattern of PNs is altered during cerebellar learning, furthermore, it has been reported that changes in the PN dendritic calcium activity are correlated with the strength and duration of a given air puff stimulus in mice. The changes in the postsynaptic voltage response of PN dendrites during learning, however, remains to be explored. The aims of my thesis project are to understand the diverse motor responses during the learning process, which reveal different patterns of conditioned responses that were not previously identified, and to investigate the corresponding changes in dendritic voltage activity during motor learning. I use the voltage sensitive dye ANNINE-6plus combined with 2-photon imaging to study high frequency dendritic complex spikes, spikelets, and dendritic spikes, as well as subthreshold post synaptic potential during delay eyeblink conditioning in habituated awake mice, as they learn for multiple days, with minimal disruption to the neuronal circuits. In addition, I established sophisticated analysis tools to analyze the high dimensional behaviour-voltage data using advanced signal extraction, signal detection, and kmeans clustering algorithms. This is the first study to investigate the gradual changes in the postsynaptic dendritic voltage responses with millisecond temporal resolution, for multiple days, during a learning task. | |||||||
| 言語 | en | |||||||
| 口頭試問日 | ||||||||
| 値 | 2024-07-04 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2024-08-31 | |||||||
| 学位名 | ||||||||
| 学位名 | Doctor of Philosophy | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第164号 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 38005 | |||||||
| 学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 権利 | ||||||||
| 権利情報 | © 2024 The Author. | |||||||
| 権利 | ||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |||||||
| 権利情報 | Creative Commons Attribution-NonCommercial-Sharealike 4.0 International | |||||||
| 開始ページ | 1 | |||||||
