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A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
https://oist.repo.nii.ac.jp/records/2044
https://oist.repo.nii.ac.jp/records/2044c7daa4e7-73ef-4d17-85ad-d4e6247f4337
名前 / ファイル | ライセンス | アクション |
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Zeberg-2021-A genomic region associated with p (845.7 kB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-05-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A genomic region associated with protection against severe COVID-19 is inherited from Neandertals | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neandertals | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | COVID-19 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | OAS1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | SARS-CoV-2 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zeberg, Hugo
× Zeberg, Hugo× Pääbo, Svante |
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書誌情報 |
en : Proceedings of the National Academy of Sciences 巻 118, 号 9, p. e2026309118, 発行日 2021-03-02 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | It was recently shown that the major genetic risk factor associated with becoming severely ill with COVID-19 when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is inherited from Neandertals. New, larger genetic association studies now allow additional genetic risk factors to be discovered. Using data from the Genetics of Mortality in Critical Care (GenOMICC) consortium, we show that a haplotype at a region on chromosome 12 associated with requiring intensive care when infected with the virus is inherited from Neandertals. This region encodes proteins that activate enzymes that are important during infections with RNA viruses. In contrast to the previously described Neandertal haplotype that increases the risk for severe COVID-19, this Neandertal haplotype is protective against severe disease. It also differs from the risk haplotype in that it has a more moderate effect and occurs at substantial frequencies in all regions of the world outside Africa. Among ancient human genomes in western Eurasia, the frequency of the protective Neandertal haplotype may have increased between 20,000 and 10,000 y ago and again during the past 1,000 y. | |||||
出版者 | ||||||
出版者 | National Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-8424 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1091-6490 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33593941 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1073/pnas.2026309118 | |||||
権利 | ||||||
権利情報 | © 2021 the Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.pnas.org/content/archive/118/9/e2026309118/1/tab-article-info?versioned=true | |||||
関連名称 | Previous version | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.pnas.org/content/118/9/e2026309118 | |||||
関連名称 | The most recent version | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |