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Multiple nutritional phenotypes of fission yeast mutants defective in genes encoding essential mitochondrial proteins
https://oist.repo.nii.ac.jp/records/2126
https://oist.repo.nii.ac.jp/records/2126dd7cc210-a2e6-4b34-b499-a8bf0bb1ab4a
名前 / ファイル | ライセンス | アクション |
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Uehara-2021-Multiple nutritional phenotypes of (1.3 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Multiple nutritional phenotypes of fission yeast mutants defective in genes encoding essential mitochondrial proteins | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mitochondria | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ts mutants | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nutritional stress | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ribosome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RNA processing | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fatty acid synthesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Uehara, Lisa
× Uehara, Lisa× Saitoh, Shigeaki× Mori, Ayaka× Sajiki, Kenichi× Toyoda, Yusuke× Masuda, Fumie× Soejima, Saeko× Tahara, Yuria× Yanagida, Mitsuhiro |
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書誌情報 |
en : Open Biology 巻 11, 号 4, p. 200369, 発行日 2021-04-07 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Mitochondria are essential for regulation of cellular respiration, energy production, small molecule metabolism, anti-oxidation and cell ageing, among other things. While the mitochondrial genome contains a small number of protein-coding genes, the great majority of mitochondrial proteins are encoded by chromosomal genes. In the fission yeast Schizosaccharomyces pombe, 770 proteins encoded by chromosomal genes are located in mitochondria. Of these, 195 proteins, many of which are implicated in translation and transport, are absolutely essential for viability. We isolated and characterized eight temperature-sensitive (ts) strains with mutations in essential mitochondrial proteins. Interestingly, they are also sensitive to limited nutrition (glucose and/or nitrogen), producing low-glucose-sensitive and 'super-housekeeping' phenotypes. They fail to produce colonies under low-glucose conditions at the permissive temperature or lose cell viability under nitrogen starvation at the restrictive temperature. The majority of these ts mitochondrial mutations may cause defects of gene expression in the mitochondrial genome. mrp4 and mrp17 are defective in mitochondrial ribosomal proteins. ppr3 is defective in rRNA expression, and trz2 and vrs2 are defective in tRNA maturation. This study promises potentially large dividends because mitochondrial quiescent functions are vital for human brain and muscle, and also for longevity. | |||||
出版者 | ||||||
出版者 | The Royal Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2046-2441 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33823662 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1098/rsob.200369 | |||||
権利 | ||||||
権利情報 | © 2021 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://royalsocietypublishing.org/doi/10.1098/rsob.200369?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |