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RNA modifications detection by comparative Nanopore direct RNA sequencing

https://oist.repo.nii.ac.jp/records/2539
https://oist.repo.nii.ac.jp/records/2539
1b7c209d-212a-4015-8f6f-73bd8a84f68e
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s41467-021-27393-3.pdf s41467-021-27393-3 (18.0 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-01-28
タイトル
タイトル RNA modifications detection by comparative Nanopore direct RNA sequencing
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者(英) Leger, Adrien

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Amaral, Paulo P.

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Pandolfini, Luca

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Capitanchik, Charlotte

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Capraro, Federica

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Miano, Valentina

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Migliori, Valentina

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Toolan-Kerr, Patrick

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Sideri, Theodora

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Enright, Anton J.

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Tzelepis, Konstantinos

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van Werven, Folkert J.

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Luscombe, Nicholas M.

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Barbieri, Isaia

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Ule, Jernej

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Fitzgerald, Tomas

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Birney, Ewan

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Leonardi, Tommaso

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Kouzarides, Tony

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書誌情報 en : Nature Communications

巻 12, 号 1, p. 7198, 発行日 2021-10-10
抄録
内容記述タイプ Abstract
内容記述 RNA molecules undergo a vast array of chemical post-transcriptional modifications (PTMs) that can affect their structure and interaction properties. In recent years, a growing number of PTMs have been successfully mapped to the transcriptome using experimental approaches relying on high-throughput sequencing. Oxford Nanopore direct-RNA sequencing has been shown to be sensitive to RNA modifications. We developed and validated Nanocompore, a robust analytical framework that identifies modifications from these data. Our strategy compares an RNA sample of interest against a non-modified control sample, not requiring a training set and allowing the use of replicates. We show that Nanocompore can detect different RNA modifications with position accuracy in vitro, and we apply it to profile m6A in vivo in yeast and human RNAs, as well as in targeted non-coding RNAs. We confirm our results with orthogonal methods and provide novel insights on the co-occurrence of multiple modified residues on individual RNA molecules.
言語 en
出版者
出版者 Nature Portfolio
ISSN
収録物識別子タイプ EISSN
収録物識別子 2041-1723
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 34893601
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 info:doi/10.1038/s41467-021-27393-3
権利
権利情報 © 2021 The Author(s).
関連サイト
識別子タイプ URI
関連識別子 https://www.nature.com/articles/s41467-021-27393-3
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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