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ゼブラフィッシュ網膜神経節細胞の生存維持と神経回路形成におけるStrip1の機能解析
https://doi.org/10.15102/1394.00002364
https://doi.org/10.15102/1394.00002364afbc9515-edd1-4169-b333-35bf8bc41e9e
| 名前 / ファイル | ライセンス | アクション |
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Ahmed - FullText (5.3 MB)
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Ahmed - FinalExamAbstract (42.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2022-04-21 | |||||||
| タイトル | ||||||||
| タイトル | ゼブラフィッシュ網膜神経節細胞の生存維持と神経回路形成におけるStrip1の機能解析 | |||||||
| 言語 | ja | |||||||
| タイトル | ||||||||
| タイトル | Investigating the Function of Strip1 in Ganglion Cell Survival and Neural Circuit Formation of the Developing Zebrafish Retina | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| ID登録 | ||||||||
| ID登録 | 10.15102/1394.00002364 | |||||||
| ID登録タイプ | JaLC | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 (英) |
Ahmed, Mai
× Ahmed, Mai
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| 抄録 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | In the vertebrate retina, an interplay between retinal ganglion cells (RGCs), amacrine and bipolar cells establishes a synaptic layer called the inner plexiform layer (IPL). This circuit conveys signals from photoreceptors to visual centers in the brain. However, the molecular mechanisms involved in its development remain poorly understood. Striatin-interacting protein 1 (Strip1) is a core component of the STRIPAK complex, and it has shown emerging roles in embryonic morphogenesis. This study uncovers the importance of Strip1 in inner retina development. Using zebrafish, I show that loss of Strip1 causes defects in IPL formation. In strip1 mutants, RGCs undergo dramatic cell death shortly after birth. Cells in the inner nuclear layer subsequently invade the degenerating RGC layer, leading to a disorganized IPL. Mechanistically, zebrafish Strip1 interacts with its STRIPAK partner, Striatin3, to promote RGC survival by suppressing Jun-mediated apoptosis. In addition to its function in RGC maintenance, Strip1 is required for RGC dendritic patterning, which likely promotes interaction between RGCs and amacrine cells for IPL formation. Taken together, I propose that a series of Strip1- mediated regulatory events coordinates inner retinal circuit formation by maintaining RGCs during development, which ensures proper positioning and neurite patterning of inner retinal neurons. | |||||||
| 口頭試問日 | ||||||||
| 値 | 2022-03-09 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2022-03-31 | |||||||
| 学位名 | ||||||||
| 学位名 | Doctor of Philosophy | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第93号 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 38005 | |||||||
| 学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 権利 | ||||||||
| 権利情報 | © 2022 The Author. | |||||||
