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A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans
https://oist.repo.nii.ac.jp/records/2725
https://oist.repo.nii.ac.jp/records/2725f545e9d9-0358-461a-ad7c-4b944a4ff520
名前 / ファイル | ライセンス | アクション |
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sciadv.abm1148 (1.0 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-08-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Coppo, Lucia
× Coppo, Lucia× Mishra, Pradeep× Siefert, Nora× Holmgren, Arne× Pääbo, Svante× Zeberg, Hugo |
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書誌情報 |
en : Science Advances 巻 8, 号 1, p. eabm1148, 発行日 2022-01-05 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals. We express the modern human and the ancestral enzymes and show that whereas the activity and stability are unaffected by the amino acid substitution, the ancestral enzyme produces more reactive oxygen species and increases cellular levels of transcripts encoding cytokines. We furthermore show that the ancestral enzyme has been reintroduced into the modern human gene pool by gene flow from Neanderthals and is associated with multiple traits in present-day people, including increased susceptibility for inflammatory-associated disorders and vascular disease. | |||||
出版者 | ||||||
出版者 | American Association for the Advancement of Science | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2375-2548 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34985944 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1126/sciadv.abm1148 | |||||
権利 | ||||||
権利情報 | © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.science.org/doi/10.1126/sciadv.abm1148 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |