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共生性渦鞭毛藻類の二次代謝のゲノム科学的洞察
https://doi.org/10.15102/1394.00000779
https://doi.org/10.15102/1394.000007793f3164af-2ce0-4302-bca9-490859b33216
| 名前 / ファイル | ライセンス | アクション |
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2019-05-10 | |||||||
| タイトル | ||||||||
| タイトル | 共生性渦鞭毛藻類の二次代謝のゲノム科学的洞察 | |||||||
| 言語 | ja | |||||||
| タイトル | ||||||||
| タイトル | Genomic insights on secondary metabolism in symbiotic dinoflagellates | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| ID登録 | ||||||||
| ID登録 | 10.15102/1394.00000779 | |||||||
| ID登録タイプ | JaLC | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 (英) |
Beedessee, Girish
× Beedessee, Girish
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| 抄録 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Dinoflagellates (division Pyrrhophyta, class Dinophyceae) are an important group of phytoplankton found in a wide range of environment reflecting a remarkable diversity in form and nutrition styles. They are typically unicellular, photosynthetic, free-swimming and form part of freshwater, brackish and marine phytoplankton communities. Dinoflagellates also produce a wide variety of secondary metabolites including toxins that are dangerous to man, marine animals, fish and other member of food chains. At present, the only available genomes of dinoflagellates are that of the family Symbiodiniaceae. Decoding higher order dinoflagellates remains a challenge because of their large nuclear genomes (up to 250 Gbp). Dinoflagellates highlight the extent of divergence that has taken place in the evolution of eukaryotic life. Taking together the economical, ecological and evolutionary importance of dinoflagellates, undertaking their genome sequencing is a valuable venture. For these reasons, this dissertation aims at understanding how the chemical diversity arises in the family Symbiodiniaceae and explain what evolutionary drivers contribute to this diversity. Next, I decode the genome of a basal dinoflagellate, Amphidinium gibossum, known to produce interesting small molecules of biological importance. The purpose of this new genome was to investigate if A. gibossum secondary metabolism differs from that of the family Symbiodiniaceae. I found that the underlying chemistry is similar, and I attempt to explain how specialized enzymes generate unique chemical diversity in them. Lastly, I focus on how nutrient starvation affect secondary metabolism in A. gibossum. In several dinoflagellates, phosphate and nitrate stress are known to increase or decrease toxin production, but the underlying transcriptomic mechanism remains limited. During such stress conditions, expression of membrane transporters for import of specific ions is upregulated and expression of secondary metabolism is correlated with nutrient availability, involving the action of miRNAs. | |||||||
| 言語 | en | |||||||
| 口頭試問日 | ||||||||
| 値 | 2019-04-05 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2019-04-30 | |||||||
| 学位名 | ||||||||
| 学位名 | Doctor of Philosophy | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第33号 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 38005 | |||||||
| 学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 権利 | ||||||||
| 権利情報 | © 2019 The Author. | |||||||
