WEKO3
Item
Intramolecular Oxa-Michael Reactions of Aldols Generated from Enones and Isatins to Afford Spirooxindole Tetrahydropyrans
https://oist.repo.nii.ac.jp/records/1177
https://oist.repo.nii.ac.jp/records/11771bf2c5a7-5676-49c7-85f1-00b5894915d3
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COM-19-S(F)26 (624.8 kB)
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Heterocycles2020,101,339sup_COM-19-S(F)26_SI.pdf (6.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| PubDate | 2020-02-17 | |||||||||||
| Title | ||||||||||||
| Title | Intramolecular Oxa-Michael Reactions of Aldols Generated from Enones and Isatins to Afford Spirooxindole Tetrahydropyrans | |||||||||||
| Language | en | |||||||||||
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| Language | eng | |||||||||||
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| Resource Type Identifier | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| Resource Type | journal article | |||||||||||
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| Access Rights | open access | |||||||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| Author |
Pasha, Maira
× Pasha, Maira
× Sohail, Muhammad
× Tanaka, Fujie
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| Bibliographic Information |
en : HETEROCYCLES Volume Number 101, Issue Number 1, p. 339-346, Issue Date 2019-08-07 |
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| Abstract | ||||||||||||
| Description Type | Other | |||||||||||
| Description | Spirooxindole derivatives are found in bioactive natural products and are used in drug discovery and related research. Here, acid-catalyzed diastereoselective intramolecular oxa-Michael cyclization reactions of β-hydroxyenones generated from enones and isatin derivatives that afford spirooxindole tetrahydropyranes are reported. The major diastereomers of the products of these reactions were previously difficult to access by the amine-catalyzed hetero-Diels-Alder reactions of enones with isatins. With the use of enantiomerically enriched forms of the starting materials in the reactions, enantiomerically enriched spirooxindole tetrahydropyranes that retained the enantiopurities of the starting materials were obtained. | |||||||||||
| Publisher | ||||||||||||
| Publisher | The Japan Institute of Heterocyclic Chemistry Publications | |||||||||||
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| Source Identifier Type | ISSN | |||||||||||
| Source Identifier | 1881-0942 | |||||||||||
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| Relation Type | isIdenticalTo | |||||||||||
| Identifier Type | DOI | |||||||||||
| Related Identifier | info:doi/10.3987/COM-19-S(F)26 | |||||||||||
| Rights | ||||||||||||
| Rights | © 2020 The Japan Institute of Heterocyclic Chemistry | |||||||||||
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| Identifier Type | URI | |||||||||||
| Related Identifier | https://www.heterocycles.jp/newlibrary/libraries/search | |||||||||||
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| Version Type | VoR | |||||||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
