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Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors

https://oist.repo.nii.ac.jp/records/1753
https://oist.repo.nii.ac.jp/records/1753
6921012a-27e9-4564-a18e-75b9652afce7
名前 / ファイル ライセンス アクション
B&B B&B Danielson et al for OISTIR - Manuscript (1.2 MB)
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
B&B B&B Danielson et al for OISTIR - SI (1.9 MB)
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-10-30
タイトル
タイトル Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Lactose biosensor
キーワード
言語 en
主題Scheme Other
主題 Field effect transistor
キーワード
言語 en
主題Scheme Other
主題 Lectin
キーワード
言語 en
主題Scheme Other
主題 Graphene
キーワード
言語 en
主題Scheme Other
主題 Gold nanoparticles
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者(英) Danielson, Eric

× Danielson, Eric

Danielson, Eric

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Dindo, Mirco

× Dindo, Mirco

Dindo, Mirco

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Porkovich, Alexander J.

× Porkovich, Alexander J.

Porkovich, Alexander J.

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Kumar, Pawan

× Kumar, Pawan

Kumar, Pawan

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Wang, Zhenwei

× Wang, Zhenwei

Wang, Zhenwei

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Jain, Prashant

× Jain, Prashant

Jain, Prashant

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Mete, Trimbak

× Mete, Trimbak

Mete, Trimbak

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Ziadi, Zakaria

× Ziadi, Zakaria

Ziadi, Zakaria

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Kikkeri, Raghavendra

× Kikkeri, Raghavendra

Kikkeri, Raghavendra

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Laurino, Paola

× Laurino, Paola

Laurino, Paola

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Sowwan, Mukhles

× Sowwan, Mukhles

Sowwan, Mukhles

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書誌情報 en : Biosensors and Bioelectronics

巻 165, p. 112419, 発行日 2020-07-03
抄録
内容記述タイプ Other
内容記述 Field-effect transistor (FET) biosensors based on low-dimensional materials are capable of highly sensitive and specific label-free detection of various analytes. In this work, a FET biosensor based on graphene decorated with gold nanoparticles (Au NPs) was fabricated for lactose detection in a liquid-gate measurement configuration. This graphene device is functionalized with a carbohydrate recognition domain (CRD) of the human galectin-3 (hGal-3) protein to detect the presence of lactose from the donor effect of lectin – glycan affinity binding on the graphene. Although the detection of lactose is important because of its ubiquitous presence in food and for disease related applications (lactose intolerance condition), in this work we exploit the lectin/carbohydrate interaction to develop a device that in principle could specifically detect very low concentrations of any carbohydrate. The biosensor achieved an effective response to lactose concentrations over a dynamic range from 1 fM to 1 pM (10−15 to 10−12 mol L−1) with a detection limit of 200 aM, a significant enhancement over previous electrochemical graphene devices. The FET sensor response is also specific to lactose at aM concentrations, indicating the potential of a combined lectin and graphene FET (G-FET) sensor to detect carbohydrates at high sensitivity and specificity for disease diagnosis.
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 0956-5663
PubMed番号
関連タイプ isVersionOf
識別子タイプ PMID
関連識別子 info:pmid/32729537
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.bios.2020.112419
権利
権利情報 This article/chapter was published in Biosensors and Bioelectronics, Volume 165, Eric Danielson, Mirco Dindo, Alexander J. Porkovich, Pawan Kumar, Zhenwei Wang, Prashant Jain, Trimbak Mete, Zakaria Ziadi, Raghavendra Kikkeri, Paola Laurino, Mukhles Sowwan, Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors, Page 112419, © 2020 Elsevier B.V.
関連サイト
識別子タイプ URI
関連識別子 https://www.sciencedirect.com/science/article/pii/S0956566320304139
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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