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Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors
https://oist.repo.nii.ac.jp/records/1753
https://oist.repo.nii.ac.jp/records/17536921012a-27e9-4564-a18e-75b9652afce7
| 名前 / ファイル | ライセンス | アクション |
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B&B Danielson et al for OISTIR - Manuscript (1.2 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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B&B Danielson et al for OISTIR - SI (1.9 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-30 | |||||
| タイトル | ||||||
| タイトル | Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lactose biosensor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Field effect transistor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lectin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Graphene | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Gold nanoparticles | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Danielson, Eric
× Danielson, Eric× Dindo, Mirco× Porkovich, Alexander J.× Kumar, Pawan× Wang, Zhenwei× Jain, Prashant× Mete, Trimbak× Ziadi, Zakaria× Kikkeri, Raghavendra× Laurino, Paola× Sowwan, Mukhles |
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| 書誌情報 |
en : Biosensors and Bioelectronics 巻 165, p. 112419, 発行日 2020-07-03 |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Field-effect transistor (FET) biosensors based on low-dimensional materials are capable of highly sensitive and specific label-free detection of various analytes. In this work, a FET biosensor based on graphene decorated with gold nanoparticles (Au NPs) was fabricated for lactose detection in a liquid-gate measurement configuration. This graphene device is functionalized with a carbohydrate recognition domain (CRD) of the human galectin-3 (hGal-3) protein to detect the presence of lactose from the donor effect of lectin – glycan affinity binding on the graphene. Although the detection of lactose is important because of its ubiquitous presence in food and for disease related applications (lactose intolerance condition), in this work we exploit the lectin/carbohydrate interaction to develop a device that in principle could specifically detect very low concentrations of any carbohydrate. The biosensor achieved an effective response to lactose concentrations over a dynamic range from 1 fM to 1 pM (10−15 to 10−12 mol L−1) with a detection limit of 200 aM, a significant enhancement over previous electrochemical graphene devices. The FET sensor response is also specific to lactose at aM concentrations, indicating the potential of a combined lectin and graphene FET (G-FET) sensor to detect carbohydrates at high sensitivity and specificity for disease diagnosis. | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0956-5663 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/32729537 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.bios.2020.112419 | |||||
| 権利 | ||||||
| 権利情報 | This article/chapter was published in Biosensors and Bioelectronics, Volume 165, Eric Danielson, Mirco Dindo, Alexander J. Porkovich, Pawan Kumar, Zhenwei Wang, Prashant Jain, Trimbak Mete, Zakaria Ziadi, Raghavendra Kikkeri, Paola Laurino, Mukhles Sowwan, Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors, Page 112419, © 2020 Elsevier B.V. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0956566320304139 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
