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大脳皮質におけるベイズ的感覚運動統合の研究
https://doi.org/10.15102/0002000454
https://doi.org/10.15102/0002000454d94dcedf-407a-4b01-afe8-93885c2bf635
| 名前 / ファイル | ライセンス | アクション |
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ZobninSergeyFulltext.pdf (6.7 MB)
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ZobninSergeyExamAbstract.pdf (48 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2024-04-15 | |||||||
| タイトル | ||||||||
| タイトル | 大脳皮質におけるベイズ的感覚運動統合の研究 | |||||||
| 言語 | ja | |||||||
| タイトル | ||||||||
| タイトル | Investigation of the Bayesian Sensory-Motor Integration in the Cerebral Cortex | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Neurophysiology | Calcium imaging | Animal behaviors | Bayesian inference | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| ID登録 | ||||||||
| ID登録 | 10.15102/0002000454 | |||||||
| ID登録タイプ | JaLC | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 (英) |
Zobnin, Sergey
× Zobnin, Sergey
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Animals need to sense their environment and differentiate sensory states to optimize behavior. For example, a force too weak may fail to pull a desired object closer, while too much effort will be unnecessarily exhausting. The prior experience interacting with similar objects can help generate the required action and produce an expectation of the sensory feedback. Combining prior expectation with the actual sensory observation is formalized with Bayes' rule. The neural mechanisms for such probabilistic computations remain unclear but, in mammals, can be attributed to the specific anatomical patterns of the cerebral cortex. In particular, the pathways carrying bottom-up sensory signals mostly terminate in layer 4 and activate pyramidal neurons of the layer 2/3 of the sensory cortex, while the neurons of deeper layers 5 and 6 mostly receive projections from other cortical areas including the motor cortex. Based on this, I hypothesized that the pyramidal neurons of the superficial layers encode sensory evidence while the deeper layer neurons encode prior and posterior estimations. I conducted a series of lever-pulling experiments on mice, where the lever provided a variable tactile feedback. Calcium imaging of the S1 cortical area using a prism lens enabled me to analyze how matches or mismatches between action-dependent prediction and actual sensory inputs are encoded by neurons in superficial and deep layers. I have identified functional asymmetry between superficial and deep cortical layers in the context of the probabilistic sensory-motor task. The deep layers were more associated with the prior information about the expected tactile stimulus in terms of the number of task coding neurons and the amount of information per given population size. In comparison with the deep layers, superficial layers were stronger associated with the sensory information about the actual tactile stimulus, but also encoded prior information. This research contributes to the study of the neural mechanisms underlying probabilistic estimation in the cerebral cortex. |
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| 言語 | en | |||||||
| 口頭試問日 | ||||||||
| 値 | 2024-01-31 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2024-03-31 | |||||||
| 学位名 | ||||||||
| 学位名 | Doctor of Philosophy | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第141号 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 38005 | |||||||
| 学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 権利 | ||||||||
| 権利情報 | © 2024 The Author. | |||||||
