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Item
The Role of Tails in Maintaining Balance: Neuronal and Behavioral Insights from the Mouse
https://doi.org/10.15102/0002000658
https://doi.org/10.15102/0002000658b82d87e1-bb74-45bf-8070-0066329b1943
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LacavaSalvatoreFulltext.pdf (45.7 MB)
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LacavaSalvatoreAbstract.pdf (48 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| PubDate | 2024-10-25 | |||||||
| Title | ||||||||
| Title | バランス維持における尾の役割：マウスからの神経学的および行動学的洞察 | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | The Role of Tails in Maintaining Balance: Neuronal and Behavioral Insights from the Mouse | |||||||
| Language | en | |||||||
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| Language | eng | |||||||
| Resource Type | ||||||||
| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002000658 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Access Right | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Author |
Lacava, Salvatore
× Lacava, Salvatore
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| Abstract | ||||||||
| Description Type | Abstract | |||||||
| Description | Tails are a distinguishing feature of animals and play a critical role in many aspects of their survival, such as maintaining balance. The present study aims to address the questions of whether and how laboratory mice (Mus musculus) use their tails to maintain balance and what are the neural mechanisms that control this behavior. To quantify how mice use their tails to maintain balance, I built a set-up (the ridge task) that simulates some of the challenges they may experience in nature. This task has led us to characterize a novel response from the tail in response to roll-plane perturbations and gave us insights onto how the tail is used during locomotion in challenging balancing conditions. In the anatomical part of the project, I will describe some of the neuronal circuits responsible for such behavior. Firstly, I characterized the morphology of tail motoneurons in the spinal cord and observed that these neurons (located in the sacral segment of the spinal cord) receive inputs from the vestibular system. Then I went on describing the subpopulation of vestibular neurons that project to the sacral spinal cord, revealing that they form a cluster mainly located in the Spinal Vestibular Nucleus. Finally, I used an optogenetic approach to stimulate either the entire vestibular nucleus, or selectively activate sacral-vestibulospinal neurons, to observe the effect of such manipulation on the tail. Intriguingly, given that the vestibular complex organization and functions are highly preserved across many taxa, the results from this project brings out exciting possibility for future studies on the organization of the neuronal control of tails in other chordates as well. | |||||||
| Exam Date | ||||||||
| 2024-08-23 | ||||||||
| Degree Conferral Date | ||||||||
| Date Granted | 2024-09-30 | |||||||
| Degree | ||||||||
| Degree Name | Doctor of Philosophy | |||||||
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| Dissertation Number | 甲第167号 | |||||||
| Degree Conferrral Institution | ||||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
| Version Format | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Copyright Information | ||||||||
| Rights | © 2024 The Author. | |||||||
| Start Page | 1 | |||||||
