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RNA decay machinery safeguards immune cell development and immunological responses
https://oist.repo.nii.ac.jp/records/2015
https://oist.repo.nii.ac.jp/records/2015d3f6fb3e-920f-41d2-8e3f-12139f4427ef
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RNA decay machinery safeguards immune cell development and immunological responses (375.4 kB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-04-27 | |||||
| タイトル | ||||||
| タイトル | RNA decay machinery safeguards immune cell development and immunological responses | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Akiyama, Taishin
× Akiyama, Taishin× Suzuki, Toru× Yamamoto, Tadashi |
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| 書誌情報 |
en : Trends in Immunology 巻 42, 号 5, p. 447-460, 発行日 2021-04-12 |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | mRNA decay systems control mRNA abundance by counterbalancing transcription. Several recent studies show that mRNA decay pathways are crucial to conventional T and B cell development in vertebrates, in addition to suppressing autoimmunity and excessive inflammatory responses. Selective mRNA degradation triggered by the CCR4-NOT deadenylase complex appears to be required in lymphocyte development, cell quiescence, V(D)J (variable-diversity-joining) recombination, and prevention of inappropriate apoptosis in mice. Moreover, a recent study suggests that mRNA decay may be involved in preventing human hyperinflammatory disease. These findings imply that mRNA decay pathways in humans and mice do not simply maintain mRNA homeostatic turnover but can also precisely regulate immune development and immunological responses by selectively targeting mRNAs. | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1471-4906 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.it.2021.03.008 | |||||
| 権利 | ||||||
| 権利情報 | This article/chapter was published in Trends in Immunology, Taishin Akiyama, Toru Suzuki, Tadashi Yamamoto, RNA decay machinery safeguards immune cell development and immunological responses, Page Nos, © Elsevier 2021. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1471490621000570 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
