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毒液の進化遺伝学：動物はどのように完璧な化学物資の武器を作るのか
https://doi.org/10.15102/1394.00002408
https://doi.org/10.15102/1394.0000240876faa1cf-7a10-44c0-b537-e46c09017c16
| 名前 / ファイル | ライセンス | アクション |
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AgneeshBarua - FullText (9.1 MB)
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AgneeshBarua - FinalExamAbstract (42.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2022-07-01 | |||||||
| タイトル | ||||||||
| タイトル | 毒液の進化遺伝学：動物はどのように完璧な化学物資の武器を作るのか | |||||||
| 言語 | ja | |||||||
| タイトル | ||||||||
| タイトル | The Evolutionary Genetics of Venoms: How Nature Created the Perfect Chemical Weapon | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| ID登録 | ||||||||
| ID登録 | 10.15102/1394.00002408 | |||||||
| ID登録タイプ | JaLC | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 (英) |
Barua, Agneesh
× Barua, Agneesh
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| 抄録 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Venomous animals have fascinated humans for millennia. How nature shaped a simple biological secretion into a potent chemical weapon is a testament to evolution’s power and versatility. However, the early origins and genetic mechanisms of venom evolution are not clearly understood. Venoms consist of proteinaceous cocktails where each protein can be mapped to a specific gene; I utilized this genetic tractability to uncover the molecular and genetic mechanisms behind its evolution. Using a combination of quantitative genetics, transcriptomics, and phylogenetics, I have identified specific mechanisms that led to the origin of oral venoms in mammals and reptiles. Oral venoms originated from an ancient conserved gene regulatory network whose primary role was maintaining cellular homeostasis during increased protein production. This ancient system could tolerate high protein loads, facilitating the parallel recruitment of various diverse protein families into the ancient venom. Venom complexity then increased by sequence and copy number variation of toxins. High copy numbers contributed to this system’s phenotypic flexibility, allowing it to further diversify through changes in evolutionary rates and by altering the combinations of toxins used. These features enabled evolution to refine venom cocktails to form optimal formulations. I provide the first unified and deep evolutionary model describing the early steps in forming a venom system and show how millions of years of evolution produced venom phenotypes in extant lineages. All chapters of this thesis have been peer-reviewed and published. | |||||||
| 口頭試問日 | ||||||||
| 値 | 2022-06-08 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2022-07-01 | |||||||
| 学位名 | ||||||||
| 学位名 | Doctor of Philosophy | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第96号 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 38005 | |||||||
| 学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 権利 | ||||||||
| 権利情報 | © 2022 The Author. | |||||||
