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小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル
https://doi.org/10.15102/1394.00002565
https://doi.org/10.15102/1394.00002565a585016d-9261-4050-9afc-3cce1f062bd6
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KatoFullText (24.2 MB)
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KatoFinalExamAbstract (42.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2022-11-10 | |||||||
| タイトル | ||||||||
| タイトル | 小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル | |||||||
| 言語 | ja | |||||||
| タイトル | ||||||||
| タイトル | A Computational Model of Granule Cell Migration and Purkinje Cell Primary Dendrite Selection during Cerebellar Development | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| ID登録 | ||||||||
| ID登録 | 10.15102/1394.00002565 | |||||||
| ID登録タイプ | JaLC | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 (英) |
Kato, Mizuki
× Kato, Mizuki
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| 抄録 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | This project aims to investigate the interrelationship between primary dendrite selection of Purkinje cells and migration of their pre-synaptic partner granule cells during cerebellar development. During development of the cerebellar cortex, each Purkinje cell grows more than three dendritic trees, among which a primary tree is selected to develop further, whereas others completely retract. Experimental studies suggested that this selection process is coordinated by physical and synaptic interactions with granule cells. However, technical limitations hinder a continuous observation on multiple populations of the cells. To reveal the mechanism underlying this selection process, we constructed a computational model of dendritic development and granule cell migration, using a new computational framework, NeuroDevSim. Comparisons of the resulting morphologies from the model demonstrated the roles of the selection stage in regulating the growth of the selected primary trees. This thesis presents the first computational model that simultaneously simulates growing Purkinje cells and the dynamics of granule cell migration, revealing the role of physical and synaptic interactions upon dendritic selection. Development of the model is expected to provide new insights in the development of neonatal Purkinje cells and help to track down how cerebellar cortex develops into a normal or abnormal structure. | |||||||
| 口頭試問日 | ||||||||
| 値 | 2022-07-21 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2022-10-31 | |||||||
| 学位名 | ||||||||
| 学位名 | Doctor of Philosophy | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第107号 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 38005 | |||||||
| 学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 権利 | ||||||||
| 権利情報 | © 2022 The Author | |||||||
