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Population Genomic Analysis of a Pitviper Reveals Microevolutionary Forces Underlying Venom Chemistry
https://oist.repo.nii.ac.jp/records/460
https://oist.repo.nii.ac.jp/records/4600ce1029b-8e9b-4600-8674-0e2517b8c49a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
evx199 (371.0 kB)
|
CreativeCommonsAttributionNon-CommercialLicense
(http://creativecommons.org/licenses/by-nc/4.0/) |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-27 | |||||
| タイトル | ||||||
| タイトル | Population Genomic Analysis of a Pitviper Reveals Microevolutionary Forces Underlying Venom Chemistry | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Aird, Steven D.
× Aird, Steven D.× Arora, Jigyasa× Barua, Agneesh× Qiu, Lijun× Terada, Kouki× Mikheyev, Alexander S. |
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| 書誌情報 |
en : Genome Biology and Evolution 巻 9, 号 10, p. 2640-2649, 発行日 2017-09-27 |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Venoms are among the most biologically active secretions known, and are commonly believed to evolve under extreme positive selection. Many venom gene families, however, have undergone duplication, and are often deployed in doses vastly exceeding the LD50 for most prey species, which should reduce the strength of positive selection. Here, we contrast these selective regimes using snake venoms, which consist of rapidly evolving protein formulations. Though decades of extensive studies have found that snake venom proteins are subject to strong positive selection, the greater action of drift has been hypothesized, but never tested. Using a combination of de novo genome sequencing, population genomics, transcriptomics, and proteomics, we compare the two modes of evolution in the pitviper, Protobothrops mucrosquamatus. By partitioning selective constraints and adaptive evolution in a McDonald–Kreitman-type framework, we find support for both hypotheses: venom proteins indeed experience both stronger positive selection, and lower selective constraint than other genes in the genome. Furthermore, the strength of selection may be modulated by expression level, with more abundant proteins experiencing weaker selective constraint, leading to the accumulation of more deleterious mutations. These findings show that snake venoms evolve by a combination of adaptive and neutral mechanisms, both of which explain their extraordinarily high rates of molecular evolution. In addition to positive selection, which optimizes efficacy of the venom in the short term, relaxed selective constraints for deleterious mutations can lead to more rapid turnover of individual proteins, and potentially to exploration of a larger venom phenotypic space. | |||||
| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| 出版者 | ||||||
| 出版者 | Society for Molecular Biology and Evolution | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1759-6653 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/29048530 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1093/gbe/evx199 | |||||
| 権利 | ||||||
| 権利情報 | © 2017 The Author(s). | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/gbe/article/9/10/2640/4259791 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
