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Lipidome Evolution in Mammalian Tissues
https://oist.repo.nii.ac.jp/records/813
https://oist.repo.nii.ac.jp/records/8139913f463-a12c-4e59-8bf6-96f95298be6c
名前 / ファイル | ライセンス | アクション |
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Khrameeva-2018 (1.2 MB)
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Creative Commons
Attribution-NonCommercial 4.0 International (https://creativecommons.org/licenses/by-nc/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-03-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Lipidome Evolution in Mammalian Tissues | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Khrameeva, Ekaterina
× Khrameeva, Ekaterina× Kurochkin, Ilia× Bozek, Katarzyna× Giavalisco, Patrick× Khaitovich, Philipp |
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書誌情報 |
en : Molecular Biology and Evolution 巻 35, 号 8, p. 1947-1957, 発行日 2018-05-11 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders. | |||||
出版者 | ||||||
出版者 | Oxford University Press on behalf of the Society for Molecular Biology and Evolution | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1537-1719 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0737-4038 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29762743 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1093/molbev/msy097 | |||||
権利 | ||||||
権利情報 | ©2018 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://academic.oup.com/mbe/article/35/8/1947/4995200 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |