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Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation
https://oist.repo.nii.ac.jp/records/814
https://oist.repo.nii.ac.jp/records/8146b672453-9642-4173-bd80-9507afed5fa7
名前 / ファイル | ライセンス | アクション |
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2723.full (2.1 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-03-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Suma, Michiko
× Suma, Michiko× Kitagawa, Teppei× Nakase, Yukiko× Nakazawa, Norihiko× Yanagida, Mitsuhiro× Matsumoto, Tomohiro |
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書誌情報 |
en : G3: Genes, Genomes, Genetics 巻 8, 号 8, p. 2723-2733, 発行日 2018-06-20 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The centromere is a chromosomal locus where a microtubule attachment site, termed kinetochore, is assembled in mitosis. In most eukaryotes, with the exception of holocentric species, each chromosome contains a single distinct centromere. A chromosome with an additional centromere undergoes successive rounds of anaphase bridge formation and breakage, or triggers a cell cycle arrest imposed by DNA damage and replication checkpoints. We report here a study in Schizosaccharomyces pombe to characterize a mutant (cnp3-1) in a gene encoding a homolog of mammalian centromere-specific protein, CENP-C. At the restrictive temperature 36 degrees , the Cnp3-1 mutant protein loses its localization at the centromere. In the cnp3-1 mutant, the level of the Cnp1 (a homolog of a centromere-specific histone CENP-A) also decreases at the centromere. Interestingly, the cnp3-1 mutant is prone to promiscuous accumulation of Cnp1 at non-centromeric regions, when Cnp1 is present in excess. Unlike the wild type protein, Cnp3-1 mutant protein is found at the sites of promiscuous accumulation of Cnp1, suggesting that Cnp3-1 may stabilize or promote accumulation of Cnp1 at non-centromeric regions. From these results, we infer the role of Cnp3 in restricting the site of accumulation of Cnp1 and thus to prevent formation of de novo centromeres. | |||||
出版者 | ||||||
出版者 | The Genetics Society of America | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2160-1836 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29925533 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1534/g3.118.200486 | |||||
権利 | ||||||
権利情報 | © 2018 Suma et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.g3journal.org/content/8/8/2723 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |