WEKO3
アイテム
Genetic regulation of mitotic competence in G0quiescent cells
https://oist.repo.nii.ac.jp/records/871
https://oist.repo.nii.ac.jp/records/8714d9e24cc-9f73-4062-a133-37a3dcc833fb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Sajiki-2018-Genetic regulation of mitotic comp (2.4 MB)
|
Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-05-16 | |||||
| タイトル | ||||||
| タイトル | Genetic regulation of mitotic competence in G0quiescent cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Sajiki, Kenichi
× Sajiki, Kenichi× Tahara, Yuria× Uehara, Lisa× Sasaki, Toshio× Pluskal, Tomáš× Yanagida, Mitsuhiro |
|||||
| 書誌情報 |
en : Science Advances 巻 4, 号 8, p. eaat5685, 発行日 2018-08-15 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Quiescent (G0 phase) cells must maintain mitotic competence (MC) to restart the cell cycle. This is essential for reproduction in unicellular organisms and also for development and cell replacement in higher organisms. Recently, suppression of MC has gained attention as a possible therapeutic strategy for cancer. Using a Schizosaccharomyces pombe deletion-mutant library, we identified 85 genes required to maintain MC during the G0 phase induced by nitrogen deprivation. G0 cells must recycle proteins and RNA, governed by anabolism, catabolism, transport, and availability of small molecules such as antioxidants. Protein phosphatases are also essential to maintain MC. In particular, Nem1-Spo7 protects the nucleus from autophagy by regulating Ned1, a lipin. These genes, designated GZE (G-Zero Essential) genes, reveal the landscape of genetic regulation of MC. | |||||
| 出版者 | ||||||
| 出版者 | American Association for the Advancement of Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2375-2548 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/30116786 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1126/sciadv.aat5685 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 The Author(s), some rights reserved; exclusive licensee American Association for the Advancement of Science. | |||||
| 情報源 | ||||||
| 関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://advances.sciencemag.org/content/4/8/eaat5685 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
